[abstract] HYPERBARIC OXYGEN RESTORES THE ANTIOXIDANT DEFENCE MECHANISM FOLLOWING EXERCISE IN PATIENTS WITH INTERMITTENT CLAUDICATION

Rubicon Research Repository/Manakin Repository

[abstract] HYPERBARIC OXYGEN RESTORES THE ANTIOXIDANT DEFENCE MECHANISM FOLLOWING EXERCISE IN PATIENTS WITH INTERMITTENT CLAUDICATION

Show simple item record


dc.contributor.author Abidia, A en_US
dc.contributor.author Kuhan, G en_US
dc.contributor.author Laden, G en_US
dc.contributor.author Bahia, H en_US
dc.contributor.author Chetter, I en_US
dc.contributor.author Greenman, J en_US
dc.contributor.author McCollum, PT en_US
dc.date.accessioned 2006-08-01T21:11:59Z
dc.date.available 2006-08-01T21:11:59Z
dc.date.issued 2001 en_US
dc.identifier.other Undersea Hyp Med 2001 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/921
dc.description Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.description.abstract BACKGROUND: Intermittent claudication represents a minor ischaemia reperfusion episode. Exposure to hyperbaric oxygen during such episodes is a concern to many vascular surgeons because of the theoretical risk of generating excess free radicals. We aimed to investigate the effect of exercise on plasma total nitric oxide and red cell glutathione levels in claudicants during hyperbaric oxygen therapy. METHODS: 4 normal subjects (NS) and 5 patients (claudicants) with peripheral arterial disease exercised to fatigue (NS) or to the limit of pain (claudicants). Venous blood samples were taken before and one minute after exercise. Claudicants repeated the same test while breathing 100percent oxygen at 2.4 atmospheres of pressure. RESULTS: Mean red cell glutathione levels was significantly reduced after exercise in claudicants, from 1211 +/-425 to 1069 +/-435 mM (p=0.043, Wilcoxon), while the levels increased in NS from 1526 +/-229 to 1727 +/-55 mM, (p=0.032, Mann-Whitney). In contrast, mean plasma total nitric oxide levels increased after exercise in claudicants from 337 +/-125 to 431 +/-126 mmol/L compared with 222 +/-49 to 309 +/-130 mmol/L in NS. Under hyperbaric oxygen conditions, exercise produced a paradoxical increase in mean red cell glutathione levels (compared with breathing air) in the claudicants group, rising from 1350 +/-552 to 1502 +/- 307 mM. CONCLUSION: Exercise to the limit of pain does not compromise nitric oxide availability but results in a significant reduction in the antioxidant defence mechanism. Hyperbaric oxygen administration normalised the glutathione response to exercise in claudicants despite the ischaemic episode and therefore warrants further research. en_US
dc.language.iso en_US
dc.rights Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.subject exercise en_US
dc.subject nitric oxide en_US
dc.subject hyperbaric en_US
dc.title [abstract] HYPERBARIC OXYGEN RESTORES THE ANTIOXIDANT DEFENCE MECHANISM FOLLOWING EXERCISE IN PATIENTS WITH INTERMITTENT CLAUDICATION en_US

Files in this item

Files Size Format View
abstract.txt 259bytes Text file View/Open

This item appears in the following Collection(s)

  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

Show simple item record

Browse

My Account