[abstract] THE EFFECT OF TWO ATMOSPHERES OXYGEN ON THE GROWTH OF MYCOBACTERIUM LEPRAE IN THE MOUSE FOOT PAD.

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[abstract] THE EFFECT OF TWO ATMOSPHERES OXYGEN ON THE GROWTH OF MYCOBACTERIUM LEPRAE IN THE MOUSE FOOT PAD.

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dc.contributor.author Gottlieb, SF
dc.contributor.author Franzblau, SG
dc.contributor.author Van Meter, KA
dc.contributor.author Sadeghani, K
dc.contributor.author Hill Jr, RK
dc.date.accessioned 2008-06-27T19:10:33Z
dc.date.available 2008-06-27T19:10:33Z
dc.date.issued 1990
dc.identifier.citation Undersea Biomedical Research, Vol. 16, No. 1 Supplement, March 1990 en
dc.identifier.uri http://archive.rubicon-foundation.org/7223
dc.description Abstract of the Undersea and Hyperbaric Medical Society, Inc. Joint Annual Scientific Meeting with the International Congress for Hyperbaric Medicine and the European Undersea Biomedical Society held 11-18 August 1990. Okura Hotel, Amsterdam, The Netherlands (http://www.uhms.org) en
dc.description.abstract Hyperbaric oxygen has been reported to be effective in treating lepromatous leprosy in humans. However, there are indications that in the mouse footpad model, hyperbaric oxygen is ineffective. It was thought that it would be beneficial to repeat the mouse footpad studies at the same pressure previously used but employing a longer duration for each period of time. It was hypothesized that the increased duration of each exposure and increased number of exposures would inhibit the in vivo growth of M. leprae. Fifty 4-week old, female BALB/c mice were inoculated in both hind footpads with 5 x 10 nude mouse-derived, Percoll-purified M. leprae. Six weeks later the mice were divided into two groups and exposed either to 1 ATA air or 2 ATA oxygen for 1.5 hours, once per day for 60 consecutive days (days 40 100 post inoculation). At 5 months post infection (7 weeks after termination of treatment), 5 mice from each group were sacrificed and the number of M. leprae determined in 10 individual footpad homogenates. The data indicate that the 2 ATA oxygen regimen herein used significantly enhanced the growth of M. leprae (3.79 x 10 acid-fast bacilli/footpad at 2 ATA O2 vs. 1.79 x 10 1 ATA air; p < 0.05). The significance of these findings will be discussed. en
dc.format.extent 193 bytes
dc.format.mimetype text/plain
dc.language.iso en en
dc.publisher Undersea and Hyperbaric Medical Society, Inc. en
dc.subject Hyperbaric Oxygenation en
dc.subject MYCOBACTERIUM LEPRAE en
dc.subject animal en
dc.subject mouse en
dc.subject foot pad en
dc.subject lepromatous leprosy en
dc.title [abstract] THE EFFECT OF TWO ATMOSPHERES OXYGEN ON THE GROWTH OF MYCOBACTERIUM LEPRAE IN THE MOUSE FOOT PAD. en
dc.type Article en

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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