[abstract] RESULTS OF COMBINATION OF HYPERBARIC OXYGEN THERAPY WTIH NALOXONE IN EXPERIMENTAL SPINAL CORD INJURY

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[abstract] RESULTS OF COMBINATION OF HYPERBARIC OXYGEN THERAPY WTIH NALOXONE IN EXPERIMENTAL SPINAL CORD INJURY

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Title: [abstract] RESULTS OF COMBINATION OF HYPERBARIC OXYGEN THERAPY WTIH NALOXONE IN EXPERIMENTAL SPINAL CORD INJURY
Author: Demircan, MN; Oztek, I; Elbuken, ME
Abstract: BACKGROUND: Ischemia and hypoxia play a role on spinal cord injury. It has been suggested that Naloxone(NLX) can improve regional blood flow in the traumatic area of the spinal cord. On the other hand HBO therapy is reasonable for tissue hypoxia and its beneficial effects has been reported. METHODS: Experimental cord traumas were performed on 30 rabbits. The animalswere divided into three groups as control, HBO-therapy and HBO-NLX combination therapy. HBO was applied as 100% O2 at 2 ATA pressure daily in one session for 2 hours in experimental pressure chamber for seven days. NLX was administered 0.4mg/kg intravenously bolus 1/2 hour before HBO-therapy. After neurologic evaluation (the scale, described by Tarlow was used for neurologic evaluation on the day of trauma and the 8th post-traumatic day) on the 8th post-traumatic day, all animals were sacrificed and their spinal cord were removed for pathologic evaluation. Stromal and cellular changes were examined under light microscope. For statistical analysis one-way Anova test, Kruskal-Wallis variance analysis test and t-test ware used. RESULTS: In control group,improvement of neurological grade was observed in one animal (F: 0.130, P>0.05). In HBO-therapy group, improvement of neurological grade were observed in seven animals (F: 7.515, P<0.05). In HBO-NLX therapy group, improvement of neurological grade were observed in six animals (F:3.115, P>0.05). As a result of pathological evaluation, there were statistically significant differences between the control and HBO-therapy ,HBO-NULX combination therapy group (P<0.05). CONCLUSION: HBO-therapy has positive effect on experimental spinal cord injury. We observed small beneficial effect of HBO-therapy neurologicaUy and NLX administration did not improve this result.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held July 7-10, 1993. World Trade and Convention Centre, Halifax, Nova Scotia, Canada.
URI: http://archive.rubicon-foundation.org/7062
Date: 1993

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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