[abstract] EFFECT OF NORMOBARIC HYPEROXIA (NH) ON REGIONAL CEREBRAL BLOOD FLOW (rCBF) BEFORE AND AFTER BRAIN MISSILE WOUNDING (BMW) IN ANESTHETIZED CATS.

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[abstract] EFFECT OF NORMOBARIC HYPEROXIA (NH) ON REGIONAL CEREBRAL BLOOD FLOW (rCBF) BEFORE AND AFTER BRAIN MISSILE WOUNDING (BMW) IN ANESTHETIZED CATS.

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Title: [abstract] EFFECT OF NORMOBARIC HYPEROXIA (NH) ON REGIONAL CEREBRAL BLOOD FLOW (rCBF) BEFORE AND AFTER BRAIN MISSILE WOUNDING (BMW) IN ANESTHETIZED CATS.
Author: Torbati, D; Carey, ME
Abstract: The cerebral vasoconstrictive effect of NH and hyperbaric oxygenation are well known. Because of hypoventilation and subsequent hypoxemia developed after CNS trauma, patients may require prompt respiratory resuscitation by high concentrations of oxygen. Vasoconstrictive effect of NH however, may further enhance the CNS trauma-induced reduction in total CBF and rCBF (Torbati et aI, 7th Int. Symp. On ICP and brain injury, In press). We tested this hypothesis measuring rCBFs (microspheres method) during air breathing and during a 10 min period of 100% oxygen breathing both before and after CNS trauma which was inflicted by BMW. Sil pentobarbital anesthetized paralyzed cats were wounded by a 2mm, 31 mg steel sphere which penetrated into the right cerebral hemisphere (velocity = 280 m/s; energy deposited 1.4 J). Before wounding, cortical structures, cerebral white matter, hippocampus, and thalamus showed 10 to 15% decrease in blood flow during hyperoxic test, while brain stem and medulla, reticular formation, cerebellar gray and white matter and cervical spinal cord showed a significant increase in blood flow (25-45%). This dual vasoconstrictive and vasodilatory effect of hyperoxia on different neuroanatomical structures in normal animals has not been described in the literature. After BMW the vasoconstrictive effect of oxygen was significantly enhanced (rCBF decreased 20 to 45%). The vasodilatory effect of NH after BMW was significantly attenuated and changed to a vasoconstrictive effect in all structures examined, except for cervical spinal cord. It is suggested that the enhancement of vasoconstrictive effect of normocapnic-NH after BMW, may counteract the possible benificial effect of hyperoxygenation to relieve tissue hypoxia. Supported by contract DAMD17-S6-C-602S, LAIR, USMRDC.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held 6-11 June 1989. Hawaiian Regent Hotel, Honolulu, Hawaii, USA (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/6762
Date: 1989

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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