[abstract] EFFECT OF INCREASED OXYGEN TENSIONS ON SURGICAL WOUNDS: CORRELATION OF HISTOLOGY WITH WOUND STRENGTH.

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[abstract] EFFECT OF INCREASED OXYGEN TENSIONS ON SURGICAL WOUNDS: CORRELATION OF HISTOLOGY WITH WOUND STRENGTH.

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Title: [abstract] EFFECT OF INCREASED OXYGEN TENSIONS ON SURGICAL WOUNDS: CORRELATION OF HISTOLOGY WITH WOUND STRENGTH.
Author: Farris, B; Gottlieb, SF; Sadeghani, K; Van Meter, K
Abstract: Hyperbaric oxygen therapy, used for treating of problem wounds, increases wound strength. We showe4 that the increased strength of a surgical wound with a partially compromised circulation is linearly related to the PO2 up to 1 ATA. The investigation herein described was designed to ascertain histologically the tissue basis for the oxygen induced increase in wound strength. The techniques were described in a companion abstract (Sadeghani et. al.). The wound was embedded in paraffin from which 4.0 thick serial sections were cut and stained with H & E. The amount of inflammation, vascular proliferation, re-epithelialization, immature and mature collagen deposition were evaluated using a semi-quantitative scale by a pathologist who was blinded with respect to the nature of the samples. With increasing PO2 up to 1.0 ATA it appeared that re-epithelialization occurred more rapidly. It was also observed that at 1.0 and 2.5 ATA O2 the rate of transformation of immature collagen to mature collagen was markedly enhanced by day four after wounding. The histological observations on collagen formation and re-epithelialization provide, in part, the explanation for the increase in wound strength previously noted. Based on the semi-quantitative scoring scale, it appears that the degree of collagen formation and epithelialization are insufficient to account for the differences in wound strength between the 1.0 and 2.5 ATA O2 exposed wounds by day 14. We are now looking at other methods of assessing the amount of collagen present in the healing wound as well las other physicochemical properties of the wound so as to help explain the greater wound strength obtained at 1 ATA oxygen.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held 6-11 June 1989. Hawaiian Regent Hotel, Honolulu, Hawaii, USA (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/6637
Date: 1989

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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