[abstract] THE EFFECT OF INCREASED OXYGEN TENSIONS ON HEALING SURGICAL WOUNDS.

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[abstract] THE EFFECT OF INCREASED OXYGEN TENSIONS ON HEALING SURGICAL WOUNDS.

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Title: [abstract] THE EFFECT OF INCREASED OXYGEN TENSIONS ON HEALING SURGICAL WOUNDS.
Author: Sadeghani, K; Gottlieb, SF; Van Meter, K; Farris, B
Abstract: Hyperbaric oxygenation is widely used in treating problem wounds. However, there is a dearth of quantitative data pertaining to wound strength as influenced by increased oxygen tension (IOT) with respect to time. This study was designed to evaluate the effect of IOT on a model surgical wound. Three 2.5 cm wounds were made on midline of backs of shaved rats. Skin was dissected from subcutaneous tissue 3 cm around each wound. Wounds were sutured using 3 No. 9 clips per wound. 60 rats, 4 weeks old, were divided into 4 equal groups. First group was exposed to 1 ATA air (0.2 ATA 02); 2nd to 2.5 ATA air (0.5 ATA 02); 3rd to 1 ATA 02; 4th to 2.5 ATA 02. Exposures were 1.5 hours twice daily. Three animals per group were sacrificed 2, 4, 6, 8 and 14 days after wounding. Two wounds were used for tensiometric measurements and one for histological analysis. Between the 2nd and 8th days there was increasing tendency for wound strength to be linearly related to PIO2 up to 1 ATA 02. Significant differences in wound strength were noted after 4 days. Increasing wound strength directly and linearly related to PI02 after 8 days, up to 1 ATA 02 (0.2 ATA_02 = 1.48 kg; 0.5 ATA 02 -1.73 kg, 1.0 ATA 02 -2.13 kg, 2.5 ATA 02 -2.11 kg) By day 14, 1.0 and 2.5 ATA 02 exposed wounds diverged: 1.0 ATA 02 stronger than 2.5 ATA 02 (3.79 vs 3.16 Kg). Wounds exposed to 1.0 ATA 02 showed linear increase in strength over 14 days. Wounds exposed to 2.5 ATA 02 showed linear strength increase in first 8 days; thereafter, 1 ATA 02 yielded significantly stronger wounds than all other oxygen tensions.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held 6-11 June 1989. Hawaiian Regent Hotel, Honolulu, Hawaii, USA (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/6629
Date: 1989

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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