[abstract] EFFECTS OF DIFFERENT INERT GASES ON THE RAT STRIATAL DOPAMINE RELEASE.

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[abstract] EFFECTS OF DIFFERENT INERT GASES ON THE RAT STRIATAL DOPAMINE RELEASE.

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Title: [abstract] EFFECTS OF DIFFERENT INERT GASES ON THE RAT STRIATAL DOPAMINE RELEASE.
Author: Balon, N; Kriem, B; Rostain, JC
Abstract: BACKGROUND: With helium pressure, mammalian developed neurological and behavioral disorders called the High Pressure Nervous Syndrome. The use of gases with higher narcotic potency induced other disorders called inert gas narcosis. In the two cases the behavioral symptoms imply neurochemical disturbances at the level of the basal ganglia. We have investigated the effect of different inert gases on the striatal dopamine release and their correlations with motor disruptions. METHODS: Males Sprague Dawley rats were anaesthetized and stereotaxically implanted with a dopamine - selective carbon electrode in the dorsal striatum. Two weeks later, free-moving animals were compressed with helium (the less narcotic, 1 bars/min, stay at 81 ATA during 2 h) or nitrogen (1 bars/min, stay at 31 ATA during 2 h) or nitrous oxide (the most narcotic, 0.1 bar/min, stay at 2 ATA during 2h, = 40%). Differential pulse voltammetry were used to measure the extracellular striatal dopamine release during all the experiments. In addition, piezoelectric sensor included under the cage floor records the behavioral changes. RESULTS: The compression of rats with helium increase from 20 bars the dopamine level (+ 60 %, n=6, p<0.05) accompanied with motor and locomotor hyperactivity (+800 %, n=6, p<0.05) and myoclonia from 50 bars (n=6, p<0.05, +55 myoclonia/l0 min at 81 ATA). Compression with nitrogen or nitrous oxide decreased the release of striatal dopamine (- 20 %, n=16, n=24, respectively, p<0.05). The behavioral changes are different from those recorded with helium, and the total motor behavior is only increased at the beginning of the compression. CONCLUSIONS: Our results indicate that the dopamine release, at the level of the nigrostriatal pathway, is implicated in the occurrence of pressure and narcosis symptoms. Pressure and narcotic gas produce antagonistic effects on striatal dopamine release.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/6516
Date: 2000

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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