[abstract] EVALUATION OF 02 AND RECOMPRESSION DEPTH IN TREATMENT OF DECOMPRESSION SICKNESS IN GUINEA PIGS.

Rubicon Research Repository/Manakin Repository

[abstract] EVALUATION OF 02 AND RECOMPRESSION DEPTH IN TREATMENT OF DECOMPRESSION SICKNESS IN GUINEA PIGS.

Show full item record


Title: [abstract] EVALUATION OF 02 AND RECOMPRESSION DEPTH IN TREATMENT OF DECOMPRESSION SICKNESS IN GUINEA PIGS.
Author: Lillo, RS; Parker, EC; MacCallum, ME
Abstract: These experiments examined whether increasing PO2, hydrostatic pressure, or both were responsible for the improvement in effectiveness of recompression treatment previously observed with increasing depths of air (1). Unanesthetized male guinea pigs (600-700 g) were subjected to 8.6 ATA air dives for 60 min and then decompressed at 1.82 ATA/min to the surface. Subsequently, animals usually displayed responses indicative of a fatal bout of decompression sickness (DCS; hypotension, cardiac arrhythmia, and tachypnea). Animals that developed DCS were treated by recompressing to depths ranging from 2.5 to 7.1 ATA, with 14%, 28%, or 42% O2/balance N2. This design produced PO2's at depth ranging from 0.4 to 3.0 ATA. Upon recompression, recovery of blood pressure, heart rate, and breathing rate generally occurred. Area under the breathing rate vs. time curve was used to examine the effectiveness of treatment over a period of 60 min. A dramatic improvement in recovery was observed with increasing recompression depth for all 3 gas mixtures. Hypothesis testing using least-squares modelling indicated that the positive response to depth was related to increasing hydrostatic pressure. Increasing PO2 appeared unimportant in this phenomenon. (1) Lillo et al., Undersea Biomed Res 15:283-300, 1988. (NOTE: http://archive.rubicon-foundation.org/2480)
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held June 23-27, 1992. Hyatt Regency Bethesda Hotel, Bethesda, Maryland (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/6378
Date: 1992

Files in this item

Files Size Format View
abstract.txt 258bytes Text file View/Open

This item appears in the following Collection(s)

  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

Show full item record

Browse

My Account