[abstract] FREE RADICAL REACTIONS IN THE INHIBITORY AND LETHAL ACTIONS OF HIGH PRESSURE GASES.

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[abstract] FREE RADICAL REACTIONS IN THE INHIBITORY AND LETHAL ACTIONS OF HIGH PRESSURE GASES.

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Title: [abstract] FREE RADICAL REACTIONS IN THE INHIBITORY AND LETHAL ACTIONS OF HIGH PRESSURE GASES.
Author: Thom, SR; Marquis, RE
Abstract: Elevated pressures of inert gases have been found to have complex actions on virtually all organisms, but the molecular details of these actions are as yet unclear. Studies of the growth modifying actions of Xe, N20, Ar, N2, He & 02, and of their effects on paraquat toxicity for Escherichia coli has lead to a view that free radicals are involved in growth inhibition and killing caused by these gases. Growth of E. coli in the presence of 13.4 ATM N20 (1.36 MPa) resulted in an induction of superoxide dismutase (SOD). Cells with elevated levels of SOD had increased resistance to the killing action of N20. The toxicity of paraquat was enhanced in the presence of N20 but not He, N2 or Ar. However, addition of any of the later three gases to N20 resulted in increased toxicity of paraquat beyond that due to N20 alone. Oxygen is known to increase the reaction of paraquat radicals within cells and to reduce leakage of the radicals out through the cell membrane. N20 and Xe appear to have this same action, and He, N2 or Ar could enhance the action of N20 or oxygen. In effect, it is possible to interpret the inhibitory and lethal actions of these gases in terms of enhanced reactivity of radicals with cell components and reduced leakage of the radicals to the environment. These findings may suggest a mechanism for some of the non-narcotic actions of inert gases.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held May 26-30, 1987. The Hyatt Regency Hotel, Baltimore, Maryland (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/5577
Date: 1987

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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