[abstract] 2, 3 DPG LEVELS DURING SATURATION DIVING TO 650 MSW.

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[abstract] 2, 3 DPG LEVELS DURING SATURATION DIVING TO 650 MSW.

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dc.contributor.author Stolp, BW
dc.contributor.author Moon, RE
dc.contributor.author Salzano, JV
dc.contributor.author Camporesi, EM
dc.date.accessioned 2008-01-04T02:23:38Z
dc.date.available 2008-01-04T02:23:38Z
dc.date.issued 1985
dc.identifier.citation Undersea Biomedical Research, Vol. 12, No. 1 Supplement, March 1985 en
dc.identifier.uri http://archive.rubicon-foundation.org/5420
dc.description Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held 11-14 June 1985. The Hyatt Regency Hotel, Long Beach, California (http://www.uhms.org) en
dc.description.abstract A factor which determines availability of 02 to tissues is the oxy-hemoglobin dissociation curve position, which is dependent in part on 2,3 DPG concentration. During a saturation dive of three healthy volunteers to pressures equivalent to 650 msw (Atlantis IV) we reported that pressure exposure was accompanied by a small leftward shift (2.3 mmHg) in P-50 of blood obtained and analyzed at depth (Stolp et al., VIII Symposium, 1984), a shift considerably smaller than expected from the work of Kiesow in vitro (UBR, 1974). We wished to test the hypothesis that pressure-induced decrease of P-50 may be accompanied by a compensatory increase in 2,3 DPG, which would tend to normalize P-50. During the dive, blood samples were obtained at various ambient pressures in order to assay the levels of 2,3 DPG (DPG), while subjects were breathing .5 ATA 02' Controls were obtained in air before and after the dive. Blood samples were rapidly fixed with perchloric acid and decompressed. DPG was assayed fluorometrically. Mean values obtained are reported in the Table as uM(DPG)/g Hb. 1 ATA Control Atlantls IV Post-dlve X ± 1 SO 15.9 ± 3.5 13.7 ± 2.6 15.1; (n) (12) (19) (2) We conclude that DPG during pressure exposure was not elevated above 1 ATA values. Furthermore, the 14% reduction in DPG was not sufficient to explain fully the magnitude of P-50 shift previously reported. en
dc.format.extent 259 bytes
dc.format.mimetype text/plain
dc.language.iso en en
dc.publisher Undersea and Hyperbaric Medical Society, Inc. en
dc.subject DIVING en
dc.subject physiology en
dc.subject oxygen hemoglobin dissociation curve en
dc.subject 2,3 DPG concentration en
dc.subject saturation en
dc.subject human en
dc.subject Atlantis IV en
dc.subject P-50 en
dc.title [abstract] 2, 3 DPG LEVELS DURING SATURATION DIVING TO 650 MSW. en
dc.type Other en

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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