[abstract] EFFECTS OF INERT GAS NARCOSIS IN RATS PERFORMING A VISUAL CHOICE REACTION TIME TASK.

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[abstract] EFFECTS OF INERT GAS NARCOSIS IN RATS PERFORMING A VISUAL CHOICE REACTION TIME TASK.

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dc.contributor.author Courtiere, A
dc.contributor.author Hardouin, J
dc.date.accessioned 2007-12-29T18:24:44Z
dc.date.available 2007-12-29T18:24:44Z
dc.date.issued 2000
dc.identifier.uri http://archive.rubicon-foundation.org/5317
dc.description Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org) en
dc.description.abstract BACKGROUND: The goal of this work was to evaluate the effects of various concentrations of nitrous oxide in rats performing a visuomotor task as a model of cognitive impairment by nitrogen narcosis. Moreover, we investigated which stage of the information processing was particularly disturbed by N20 inhalation. METHODS: 13 Long Evans rats were trained in an operant chamber for responding to eccentric visual stimuli by lever release (reaction time) and consecutive head entrance into a lateral hole (movement time) related to the location of the stimulus. During the test, various concentrations of nitrous oxide (from 0 percent to 50 percent) were evaluated in association with the manipulation of various parameters of the task (stimulus luminance and foreperiod duration). The influence of these variables permitted to determine the outcomes of nitrous oxide on reaction time (RT) and movement time (MT), the former variable being analysed according to the additive factor method. RESULTS: Under N2O, RT and MT evolved in an opposite way. RT was progressively increased under N2O whereas MT was decreased. Considering RT, its increase occurred from 50 percent N2O for long foreperiod sessions and from 30 percent to 50 percent N2O for short foreperiod sessions, underlying the fact that uncertainty of signal occurrence interacts with N2O effects. On the other hand, there is a purely additive effect on RT of manipulating the stimulus luminance. CONCLUSIONS: The RT component of the response being reflective of "mental operations", it is concluded that N2O interferes with information processing by slowing underlying processes. More precisely, it is concluded that this slowing acts at least through the interaction of the motor stage of information processing, these results being at variance with Fowler's conclusions of an overall additivity of N2O narcosis on all stages of information processing, revealing a depressing effect of N2O on central nervous system. en
dc.format.extent 193 bytes
dc.format.mimetype text/plain
dc.language.iso en_US en
dc.subject inert en
dc.subject gas en
dc.subject narcosis en
dc.subject animal en
dc.subject rat en
dc.subject visual en
dc.subject choice en
dc.subject N2O en
dc.subject cognitive en
dc.title [abstract] EFFECTS OF INERT GAS NARCOSIS IN RATS PERFORMING A VISUAL CHOICE REACTION TIME TASK. en
dc.type Article en

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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