[abstract] STARVATION AND DEHYDRATION ATTENUATES CNS OXYGEN TOXICITY IN RATS

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[abstract] STARVATION AND DEHYDRATION ATTENUATES CNS OXYGEN TOXICITY IN RATS

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Title: [abstract] STARVATION AND DEHYDRATION ATTENUATES CNS OXYGEN TOXICITY IN RATS
Author: Bitterman, N; Sckapa, E; Gutterman, A
Abstract: BACKGROUND: Previous reports suggest a possible protective effect of starvation on CNS oxygen toxicity. Since starvation and dehydration might accompany exposure to HBO both in the clinical setting and diving conditions, we decided to test the effect of graded food and water deprivation and a combination of the two, for 24 and 36 hr, on the sensitivity to CNS oxygen toxicity in rats. METHODS: Male rats implanted with chronic cortical electrodes for continuous EEG monitoring were used. Seventy rats were exposed to 7 experimental protocols (10 rats in each group): Starvation or dehydration or their combination for 24 or 36 hr, prior to exposure to 0.5MPa oxygen. Control rats had access ad lib to both food and water. The duration of the latent period until the appearance of electrical discharges in the EEG was used as an index of CNS oxygen toxicity. Blood and urine samples were taken for biochemical follow up. RESULTS: Significant prolongation of the latent period compared with control was found in all starved and dehydrated rats (P less than 0.05) in the tukey test), except for the 24 hr starvation rats. CONCLUSION: Our results suggest that relatively short-term deprivation of food or water, prior to exposure to HBO, might be used to obtain significant protection against hyperoxia-induced seizures.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/528
Date: 1996

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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