[abstract] RATE OF HYPERBARIC OXYGEN TREATMENT IN SOFT TISSUE RADIONECROSIS: DOES IT AFFECT OUTCOME?

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[abstract] RATE OF HYPERBARIC OXYGEN TREATMENT IN SOFT TISSUE RADIONECROSIS: DOES IT AFFECT OUTCOME?

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Title: [abstract] RATE OF HYPERBARIC OXYGEN TREATMENT IN SOFT TISSUE RADIONECROSIS: DOES IT AFFECT OUTCOME?
Author: Hampson, NB; Corman, JM
Abstract: BACKGROUND: Soft tissue radionecrosis is treated with hyperbaric oxygen (HBO2), typically with 30-40 treatments. It is not known whether the effectiveness of HBO2 differs as a function of the rate of administration of those treatments. Various hyperbaric facilities treat such patients from 5-7 days weekly and from 1-2 times daily, depending upon patient preference and scheduling constraints. To determine whether the rate of HBO2 administration influences outcome, we analyzed the results from our patient population treated for soft tissue radionecrosis of the bladder (radiation cystitis). MATERIALS AND METHODS: Records of patients treated with HBO2 for hemorrhagic radiation cystitis at Virginia Mason Medical Center from 1988 to 2006 were reviewed. Data extracted included patient demographic and disease information, hyperbaric treatment details, and response to therapy with regard to hemorrhage. Patients were classified as responders (hemorrhage significantly improved or resolved) and nonresponders (hemorrhage unchanged or worse) following an initial course of HBO2 therapy. Response was then compared to hyperbaric treatment details. RESULTS: Of 94 total patients, 78 (83%) were responders to HBO2 on an intent-to-treat basis. There was no significant difference in outcome between patients who averaged 5 or fewer HBO2 treatments per week vs. those who received more than 5 treatments per week (p=0.2794, Fisher’s Exact Test), or between those who averaged < 3 vs. > 7 treatments weekly (p=1.000). Responders averaged from 2 to 12 treatments per week over their course (mean 5+1), while nonresponders averaged from 2 to 10 treatments per week (6+2). Total number of treatments administered, however, did correlate with response. Those who received 30 or more total treatments had a better response rate than those who received fewer (p=0.0432). CONCLUSIONS: Among patients treated for this form of soft tissue radionecrosis, we found no difference in response related to rate of hyperbaric treatment. Once or twice daily treatment can be administered with equal confidence for similar outcome.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held June 14-16, 2007. Ritz-Carlton Kapalua Maui, Hawaii (http:www.uhms.org)
URI: http://archive.rubicon-foundation.org/5094
Date: 2007

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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