[abstract] GROWTH INHIBITION BY ANESTHETIC GASES APPEARS NOT TO BE A GENERAL NARCOTIC EFFECT.

Rubicon Research Repository/Manakin Repository

[abstract] GROWTH INHIBITION BY ANESTHETIC GASES APPEARS NOT TO BE A GENERAL NARCOTIC EFFECT.

Show full item record


Title: [abstract] GROWTH INHIBITION BY ANESTHETIC GASES APPEARS NOT TO BE A GENERAL NARCOTIC EFFECT.
Author: Thom, SR; Marquis, RE
Abstract: The noble gases and gaseous anesthetics such as nitrous oxide are thought to cause narcosis simply by acting as inert, space-occupying molecules that dissolve in cell membrane lipids. We have tested the effects of these gases on growth of three bacteria - Streptococcus faecalis, Staphylococcus aureus and Escherichia coli. The actions of these agents were manifest by changes in growth rates and maximal yields of cultures, determined by means of turbidity measurements, direct counting and viable counting. The results indicated that the actions were not ones that would be predicted on the basis of the critical volume hypothesis {CVH}. Helium enhanced growth, as one might expect from its negative narcotic potential. However, this effect was nearly constant over a range of helium partial pressures from 20 to 70 atmospheres. Surprisingly, argon also enhanced growth. Nitrogen fell out of its expected place in the CVH potency series in that even at pressures as high as 70 atmospheres it had no effect on growth. Noble gases with molecular dimensions greater than those of argon inhibited growth, and potency increased with molecular size. All the gases, except for nitrogen, were potentiating for the growth inhibitory action of nitrous oxide, even helium and argon which alone enhanced growth. Also, all the gases tested exacerbated the toxicity of oxygen. Sensitivity to the gases was found to vary quantitatively among the species of bacteria tested and it could be modified by changing the culture pH or content of divalent cations. Overall, it appears that the growth inhibitory actions of anesthetic gases are not reflections of some general narcotic or anesthetic effect but are a unique class of actions.
URI: http://archive.rubicon-foundation.org/4292
Date: 1978

Files in this item

Files Size Format View
abstract.txt 193bytes Text file View/Open

This item appears in the following Collection(s)

  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

Show full item record

Browse

My Account