[abstract] THE RAT AS A DECOMPRESSION MODEL: EVIDENCE FOR PRE-EXISTING GASEOUS MICRONUCLEI.

Rubicon Research Repository/Manakin Repository

[abstract] THE RAT AS A DECOMPRESSION MODEL: EVIDENCE FOR PRE-EXISTING GASEOUS MICRONUCLEI.

Show full item record


Title: [abstract] THE RAT AS A DECOMPRESSION MODEL: EVIDENCE FOR PRE-EXISTING GASEOUS MICRONUCLEI.
Author: Vann, RD; Grimstad, JJ; Nielsen, CH; Carey, BA
Abstract: To study the rat as a decompression model and to investigate bubble formation, 495 male Wistar rats were exposed on one of three dive profiles to compressed air for 2 hrs followed by decompression to the surface at 60 fpm: (a) 100 rats were exposed at 210 fsw; (b) 200 rats at 240 fsw; (c) after a 1 minute excursion to 600 fsw with a 9 minute total excursion time from 0 to 600 to 240 fsw, 195 rats were exposed at 240 fsw for 2 hours. The bends incidences based upon rats tumbling in a rotating cage were 41 percent, 83 percent and 74 percent respectively for profiles a, b, and c. Statistically reliable results were achieved with sample sizes of 75-100 rats on each profile. Rats exposed in the morning were 14 percent more likely to suffer bends than rats exposed in the early afternoon. A regression line fit to the data indicates that the bends incidence increased 1 percent per 10 gm in a population having a 221 to 410 gm weight range. The reduction in bends incidence of 9 percent between 240 fsw dives with and without the 600 fsw brief excursion (significant at P less or equal to 0.01) suggests that bubbles responsible for bends in the rat grow from pre-existing gaseous micronuclei some of which are forced into solution during the excursion to 600 fsw.
URI: http://archive.rubicon-foundation.org/4232
Date: 1978

Files in this item

Files Size Format View
abstract.txt 193bytes Text file View/Open

This item appears in the following Collection(s)

  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

Show full item record

Browse

My Account