[abstract] RATIONALE AND DESIGN OF THE HYPERBARIC OXYGEN TREATMENT IN DIABETICS WITH CHRONIC FOOT ULCERS STUDY (HODFU)

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[abstract] RATIONALE AND DESIGN OF THE HYPERBARIC OXYGEN TREATMENT IN DIABETICS WITH CHRONIC FOOT ULCERS STUDY (HODFU)

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Title: [abstract] RATIONALE AND DESIGN OF THE HYPERBARIC OXYGEN TREATMENT IN DIABETICS WITH CHRONIC FOOT ULCERS STUDY (HODFU)
Author: Landahl, M; Katzman, P; Nilsson, A; Hammarlund, C; Apelqvist, J
Abstract: BACKGROUND: Diabetic foot ulcers are not only a costly and disabling clinical problem, but also one of the most common and devastating complications of diabetes mellitus. Despite improvement due to a multidisciplinary team approach, amputation rate and frequency of unhealed ulcers are still too high, and the need for adjunct treatment strategies persists. Diabetic foot ulcers are characterised by ischemia and infection. Hyperbaric oxygen therapy (HBOT) may be a treatment modality to improve oxygenation of ischemic tissue. Previous studies indicate beneficial effect of HBOT on ulcer healing and amputation frequency in patients with diabetes mellitus. However, the question whether diabetic foot ulcer is an indication for HBOT is still under debate, since none of the previous studies is without methodological problems. The final conclusion of an analysis completed in 2004 by the Cochrane Collaboration was that further research is needeMATERIALS AND METHODS: In this abstract we discuss and review data from previous studies investigating the effect of HBOT on healing chronic foot ulcer in patients with diabetes mellitus. We further present the design of the HODFU study, a single centre, prospective, randomised, double-blind study, designed to evaluate the effects of HBOT (2,5 ATM) as compared to placebo (air-breathing under hyperbaric conditions (2,5 ATA)) on ulcer healing in patients with diabetes mellitus and chronic foot ulcers.Patients are followed for 2 years. The primary objective of the study is to assess the effect of HBOT on ulcer healing to intact skin. The secondary objectives are to assess the effect of HBOT on amputation rate, retinopathy, quality of life and health economics. Furthermore, metabolic or local factors impact on ulcer healing will be analysedRESULTS: Inclusion is ongoingCONCLUSIONS: In this abstract the rational and design of the HODFU study is presented.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/3666
Date: 2006

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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