[abstract] RADIOGRAPHIC EVALUATION OF BONY HEALING OF RABBIT CRITICAL-SIZED CALVARIAL DEFECTS WITH HYPERBARIC OXYGEN THERAPY

Rubicon Research Repository/Manakin Repository

[abstract] RADIOGRAPHIC EVALUATION OF BONY HEALING OF RABBIT CRITICAL-SIZED CALVARIAL DEFECTS WITH HYPERBARIC OXYGEN THERAPY

Show full item record


Title: [abstract] RADIOGRAPHIC EVALUATION OF BONY HEALING OF RABBIT CRITICAL-SIZED CALVARIAL DEFECTS WITH HYPERBARIC OXYGEN THERAPY
Author: Jan, AM; Evans, AW; Mhawi, A; Peel, S; Clokie, CM; Sandor, GK
Abstract: BACKGROUND: A critical-sized defect is the smallest osseous wound that will not heal spontaneously during the experimental period. In a related experiment Hyperbaric oxygen therapy (HBO) has been demonstrated to induce bony union in defects larger than the critical-size of the rabbit calvarial defect. We evaluated whether radiomorphometric evaluation can demonstrate the effects of HBO in inducing bony union in the rabbit critical-sized calvarial defect model. MATERIALS AND METHODS: Twenty New Zealand rabbits were divided into 2 groups of 10 animals each. Full thickness calvarial defects were created in their parietal bones bilaterally. Defects were critical-sized, 15x13 mm in one side and supracritical sized, 18x13 mm in the contralateral side. Group1 received 90 minutes HBO therapy sessions at 2.4 ATA per day for 20 consecutive days. Group 2 served as controls. Five animals in each group were sacrificed at 6 and 12 weeks postoperatively. Data analysis included quantitative assessment of post sacrifice radiographs to measure the amount of radioopacities within the defects. RESULTS: HBO treated defects demonstrated more radioopacities than the control ( p less than .001). The control defects were covered with a radiolucent shadow in both defects. Using ANOVA and paired samples t-test, no difference was found in areas of radioopacities within the 15 mm and 18 mm defects ( p greater than .05 ). In the HBO group, the 12 weeks samples had more radioopacities than the 6 weeks group ( p = .019). CONCLUSIONS: HBO therapy has been demonstrated, in other studies, to extend the critical size of the rabbit calvarial defects beyond 20percent. This study confirms this finding using the same model, but a different modality, namely radiographic analysis. The difference demonstrated in the 6 and 12 weeks HBO defects is physiologically consistent with the fact that radiographs may not detect bone unless it is considerably mineralized.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1769
Date: 2005

Files in this item

Files Size Format View
abstract.txt 259bytes Text file View/Open

This item appears in the following Collection(s)

  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

Show full item record

Browse

My Account