[abstract] EXPOSURE OF NEWBORN RAT PUPS TO A SINGLE TREATMENT OF HYPEROXIA AT NORMOBARIC AND HYPERBARIC PRESSURES DOES NOT CAUSE RETINOPATHY OF PREMATURITY

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[abstract] EXPOSURE OF NEWBORN RAT PUPS TO A SINGLE TREATMENT OF HYPEROXIA AT NORMOBARIC AND HYPERBARIC PRESSURES DOES NOT CAUSE RETINOPATHY OF PREMATURITY

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Title: [abstract] EXPOSURE OF NEWBORN RAT PUPS TO A SINGLE TREATMENT OF HYPEROXIA AT NORMOBARIC AND HYPERBARIC PRESSURES DOES NOT CAUSE RETINOPATHY OF PREMATURITY
Author: Calvert, J; Zhou, C; Nanda, A; Zhang, J
Abstract: INTRODUCTION: Hyperoxia has been shown to reduce brain damage in neonatal rat pups subjected to a hypoxic-ischemic insult. It has also been linked to vision-threatening retinopathy. The purpose of this study was to examine the possibility of hyperoxia in inducing vision-threatening retinopathy. METHODS: Newborn rat pups were exposed to 100 percent oxygen at 1, 1.5, or 3.0 ATA for one hour, the same treatment protocol used for brain protection after hypoxia-ischemia. Retinopathy was evaluated by the degree of neovascularization (measuring retinal vascular density), by the structural abnormalities (histology) in the retina, and by the expression of hypoxia-hyperoxia sensitive proteins including hypoxia-inducible factor-1E- (HIF-1E-) and Vascular Endothelial Growth Factor (VEGF) at 24 hrs, 1, 2 and 10 weeks after hyperoxia exposure. RESULTS: Retinal vascular density measurements revealed no signs of neovascularization after hyperoxia exposure. There were also no abnormalities in the structure of the retina and no changes in the protein expression of HIF-1E- and VEGF following hyperoxia exposure. CONCLUSIONS: Exposure to hyperoxia for one hour at normobaric or hyperbaric pressures did not result in the structural changes or abnormal vascularization that is associated with retinopathy of prematurity. This suggests that single hyperoxia is a safe treatment for hypoxic or immature infants.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1563
Date: 2004

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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