[abstract] RADIATION THERAPY AFTER HYPERBARIC OXYGENATION: A REVIEW

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[abstract] RADIATION THERAPY AFTER HYPERBARIC OXYGENATION: A REVIEW

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Title: [abstract] RADIATION THERAPY AFTER HYPERBARIC OXYGENATION: A REVIEW
Author: Kohshi, K; Inoue, O; Beppu, T; Sminia, P
Abstract: BACKGROUND: The presence of hypoxic cells is one of major reasons for failure to control malignant tumors. Although hyperbaric oxygen (HBO) therapy was previously used to improve radiation effect for many cancer treatments, irradiation during HBO exposure was hazardous for patients and a complex technique. To solve these problems, a new approach, radiation therapy after HBO exposure, has been applied in some institutes. The aim of this study is to present the state of the art with regard to this new therapeutic regimen for cancer treatments. METHODS: We reviewed articles concerning this approach in clinical and experimental studies. RESULTS: All treated cancers were malignant brain tumors (gliomas), and some clinical trials showed a prolonged survival such as 1.5 to 2 times of previously reported results. Serious side effects have not been reported. This therapeutic effectiveness was confirmed in an experimental tumor model (radiobiological hypoxic fraction of approx. 10percent). Both clinical and experimental studies showed that high O2 concentration was kept for 30 - 40 minutes after the end of HBO exposure. CONCLUSION: This combined therapy, irradiation after HBO exposure, seems to be useful for treatment of patients with malignant gliomas including many solid malignant tumors. In order to provide more convincing evidence of the therapeutic effect, randomized clinical trials should be undertaken.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1556
Date: 2004

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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