[abstract] RANDOMIZED TRIAL CARBON MONOXIDE POISONED PATIENTS COMPARED TO NON-RANDOMIZED PATIENTS.

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[abstract] RANDOMIZED TRIAL CARBON MONOXIDE POISONED PATIENTS COMPARED TO NON-RANDOMIZED PATIENTS.

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Title: [abstract] RANDOMIZED TRIAL CARBON MONOXIDE POISONED PATIENTS COMPARED TO NON-RANDOMIZED PATIENTS.
Author: Weaver, LK; Hopkins, RO; Churchill, S; Chan, KJ
Abstract: BACKGROUND: In a recent randomized clinical trial (RCT), hyperbaric oxygen (HBO2) compared to normobaric oxygen (NBO2) therapy reduced cognitive sequelae due to acute carbon monoxide (CO) poisoning.1 In this abstract, we compared outcome of RCT patients to CO-poisoned, non-RCT patients. METHODS: 152 patients were enrolled in a RCT.1 106 CO-poisoned non-RCT patients had identical prospective follow-up as the RCT patients, at onset, 24 hours, 2-weeks, 6-weeks, 6-months, and 12-months after poisoning. These patients either declined the RCT or failed to meet enrollment criteria for reasons listed in Fig. 3, of ref. 1. RESULTS: All RCT patients were treated 3x with HBO2 or NBO2.1 Non-RCT patients were treated with supplemental oxygen by endotracheal tube (7), non-rebreather face mask (54), face mask (3), nasal cannula (4), and no supplemental oxygen (39). Baseline characteristics compared across groups: HBO2 (n=76) NBO2 (n=76) non-RCT (n=106) p-value. Female (percent) 28.9 28.9 43.7 0.053, LOC (percent) 48.7 50.0 35.4 0.091, Suicide attempt (percent) 35.5 26.3 8.7 less than 0.001, Education Level 12.3+3.0 11.9+3.8 13.2+2.1 0.007, Initial COHb 24.9+9.6 25.3+8.7 12.7+12.5 less than 0.001, Age 34.6+10.3 35.9+14.6 36.3+15.2 0.700, mean+SD ANOVA. Cognitive sequelae (percent), HBO2 NBO2 non-RCT p-value. 6-weeks (percent) 24.0 43.1 37.1 0.044, 6-months (percent) 14.3 30.9 23.2 0.067, 12-months (percent) 12.7 26.1 16.2 0.098. Chi-square, At 6-weeks, cognitive sequelae in the HBO2 group were lower than in the NBO2 group (p=0.014),1 and a trend for the non-RCT patients (p=0.066). There was no difference in cognitive sequelae between the NBO2 and non-RCT groups (p=0.435). CONCLUSIONS: Cognitive sequelae were lower in patients treated with HBO2, compared to NBO2 or non-RCT patients. Non-RCT patients are not well matched to RCT patients, yet have cognitive sequelae rates comparable to the NBO2 group (6-weeks). The cognitive sequelae rate may be influenced by 37percent of the non-RCT patients not receiving supplemental oxygen.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1358
Date: 2003

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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