Dual effects of hyperbaric oxygen on proliferation and cytotoxic T lymphocyte activity of rat splenic lymphocytes.

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Dual effects of hyperbaric oxygen on proliferation and cytotoxic T lymphocyte activity of rat splenic lymphocytes.

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dc.contributor.author Liu, W en_US
dc.contributor.author Zhang, J en_US
dc.contributor.author Ma, C en_US
dc.contributor.author Liu, Y en_US
dc.contributor.author Li, R en_US
dc.contributor.author Sun, X en_US
dc.contributor.author Zhang, J en_US
dc.contributor.author Xu, WG en_US
dc.date.accessioned 2014-03-20T04:30:07Z
dc.date.available 2014-03-20T04:30:07Z
dc.date.issued 2009 en_US
dc.identifier.citation Undersea Hyperb Med. 2009 May-Jun;36(3):155-60. en_US
dc.identifier.isbn 1066-2936 en_US
dc.identifier.other 19860137 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/10385
dc.description Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. en_US
dc.description.abstract Contradictory reports exist regarding the effects of hyperbaric oxygen (HBO2) on immune functions. We hypothesized that the intensity of exposure is a key factor, which leads to the different effects of HBO2 on immunity. In this study, we determined the function of rat splenic lymphocytes after in vitro exposure to different pressure-durations of HBO2. The proliferation rate and total cytotoxic T lymphocyte (CTL) activity stimulated by concanavalin A were enhanced by exposure to low (100 kPa for 60 or 90 minutes and 150 kPa for 30 or 60 minutes) HBO2 pressure-durations, but were inhibited by exposure to higher pressure-durations. We conclude that HBO2 exerts dual effects on lymphocyte function, as appropriate exposure promotes and excessive exposure inhibits the functions. en_US
dc.language.iso en en_US
dc.publisher Undersea and Hyperbaric Medical Society, Inc. en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Cell Proliferation/*drug effects en_US
dc.subject.mesh *Hyperbaric Oxygenation en_US
dc.subject.mesh Immunity, Cellular/drug effects en_US
dc.subject.mesh Male en_US
dc.subject.mesh Oxygen/*pharmacology en_US
dc.subject.mesh Rats en_US
dc.subject.mesh Rats, Sprague-Dawley en_US
dc.subject.mesh Spleen/*cytology en_US
dc.subject.mesh T-Lymphocytes, Cytotoxic/*drug effects/physiology en_US
dc.subject.mesh Time Factors en_US
dc.title Dual effects of hyperbaric oxygen on proliferation and cytotoxic T lymphocyte activity of rat splenic lymphocytes. en_US
dc.type Article en_US

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