[abstract] HBO2T and radiation nephritis: Case report and review of the literature

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[abstract] HBO2T and radiation nephritis: Case report and review of the literature

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Title: [abstract] HBO2T and radiation nephritis: Case report and review of the literature
Author: Perdrizet, GA; Althoff, M
Abstract: Introduction: Radiation nephritis is a known complication of radiation therapy involving the kidneys. Methods/Results: Case report – JL is a 9year-old African American female s/p left nephrectomy and combined chemotherapy and radiation therapy for stage I anaplastic nephroblastoma (Wilms tumor) diagnosed nine months prior to presentation. At the time of hyperbaric consultation, the patient had been admitted to the pediatric intensive care unit for workup and management of uncontrollable hypertension and worsening renal function. A diagnosis consistent with radiation nephritis was made by scanning electron microscopy. She had received 3,000cGY of X-radiation to the abdominal cavity and retroperitoneum six months prior to consultation. She also had received six of 10 rounds of chemotherapy (cytoxan, carboplatin, adriamycin, etoposide and vincristine). The patient was seen by HBO2 physician and no contraindication to HBO2T was encountered, including no evidence of residual/recurrent tumor and no exposure to bleomycin. After consultation with the patient and mother, informed consent (parent) and assent (child) were obtained for HBO2 treatment. The patient received 32 treatments (2.5 ATA x 90 minutes) over a 59-day time period. There were no complications associated with the hyperbaric treatments. During the fourth week of treatment, the patient’s blood pressure became better controlled and by completion of the 20th session, renal function had returned to normal. A detailed presentation of the patient’s clinical course (blood pressure, serum and urine chemistries) will be presented, along with a review of the current literature on the pathophysiology and management of radiation nephritis. Summary: Radiation nephritis and uncontrolled hypertension in a child with a single kidney carries a high risk for progression to complete renal failure. HBO2T was provided with minimal risk and was temporally associated with improvement in the patient’s clinical condition.
Description: Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc.
URI: http://archive.rubicon-foundation.org/9930
Date: 2011

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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