Functional changes in microcirculation during hyperbaric and normobaric oxygen therapy.

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Functional changes in microcirculation during hyperbaric and normobaric oxygen therapy.

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dc.contributor.author Stirban, A en_US
dc.contributor.author Lentrodt, S en_US
dc.contributor.author Nandrean, S en_US
dc.contributor.author Pop, A en_US
dc.contributor.author Tschoepe, D en_US
dc.contributor.author Scherbaum, WA en_US
dc.date.accessioned 2011-10-31T12:30:06Z
dc.date.available 2011-10-31T12:30:06Z
dc.date.issued 2009 en_US
dc.identifier.citation Undersea Hyperb Med. 2009 Sep-Oct;36(5):381-90. en_US
dc.identifier.isbn 1066-2936 en_US
dc.identifier.other 20112529 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/9373
dc.description Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. en_US
dc.description.abstract OBJECTIVES: Treatment of cutaneous wounds is one of the many applications of hyperbaric oxygen therapy (HBO). However, the complex regulation of skin microcirculation during different phases of HBO is not completely understood. We therefore investigated skin microcirculation and oxygenation during HBO and normobaric oxygen (NBO) exposure. METHODS: Seven healthy volunteers were investigated using measurements of transcutaneous oxygen pressure (PtcO2), tissue spectrophotometry and laser Doppler flowmetry recorded simultaneously in the hand and foot during HBO and NBO in 2- and 4-mm depths. We defined tissue hypoxia as a PtcO2 below 30 mmHg. RESULTS: At the hand, in 2 mm depth, NBO induced a mild vasoconstriction (-37 percent, p=0.07), but a significant increase in PtcO2 (+380 percent, p less than 0.001). HBO induced a mild vasoconstriction (-45 percent, p=0.08), significantly increasing PtcO2 (+1430 percent, p less than 0.001). Hand changes in 2 and 4 mm were comparable. Foot changes were smaller than at the hand and more pronounced in 4 mm than in 2 mm depth during NBO and compression. No episodes of tissue hypoxia occurred at any time. CONCLUSIONS: In healthy subjects, NBO and especially HBO significantly improve tissue oxygenation, despite vasoconstriction. Differences in vascular regulation between hand and foot and especially at the latter site between 2 and 4 mm depth exist. en_US
dc.language.iso en en_US
dc.publisher Undersea and Hyperbaric Medical Society, Inc. en_US
dc.subject HBO en_US
dc.subject vasoconstriction en_US
dc.subject oxygen en_US
dc.subject.mesh Adult en_US
dc.subject.mesh Blood Flow Velocity/physiology en_US
dc.subject.mesh Blood Gas Monitoring, Transcutaneous/methods en_US
dc.subject.mesh Female en_US
dc.subject.mesh Foot/blood supply en_US
dc.subject.mesh Hand/blood supply en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Hyperbaric Oxygenation en_US
dc.subject.mesh Laser-Doppler Flowmetry/methods en_US
dc.subject.mesh Male en_US
dc.subject.mesh Microcirculation/*physiology en_US
dc.subject.mesh Middle Aged en_US
dc.subject.mesh *Oxygen Inhalation Therapy en_US
dc.subject.mesh Regional Blood Flow/physiology en_US
dc.subject.mesh Skin/*blood supply en_US
dc.subject.mesh Spectrophotometry/methods en_US
dc.subject.mesh Vasoconstriction/*physiology en_US
dc.title Functional changes in microcirculation during hyperbaric and normobaric oxygen therapy. en_US
dc.type Article en_US

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