Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning.

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Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning.

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dc.contributor.author Chang, DC en_US
dc.contributor.author Lee, JT en_US
dc.contributor.author Lo, CP en_US
dc.contributor.author Fan, YM en_US
dc.contributor.author Huang, KL en_US
dc.contributor.author Kang, BH en_US
dc.contributor.author Hsieh, HL en_US
dc.contributor.author Chen, SY en_US
dc.date.accessioned 2011-10-07T20:30:10Z
dc.date.available 2011-10-07T20:30:10Z
dc.date.issued 2010 en_US
dc.identifier.citation Undersea Hyperb Med. 2010 Jan-Feb;37(1):23-33. en_US
dc.identifier.isbn 1066-2936 en_US
dc.identifier.other 20369650 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/9302
dc.description Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. en_US
dc.description.abstract OBJECTIVES: Delayed neuropsychiatric syndrome (DNS) is characterized by mental impairment, motor dysfunction, dementia, or psychosis that develops between a few days and weeks after acute carbon monoxide (CO) poisoning. One possible mechanism responsible for CO-mediated encephalopathy involves oxidative stress, such as lipid peroxidation, caused by the cellular uptake of CO and which leads to an inflammatory cascade. There is no current effective treatment for DNS. We applied 8-40 sessions of hyperbaric oxygen therapy (HBO2) to patients with DNS and evaluated its effectiveness. METHODS: After admission, all patients were administered piracetam or bromocriptine, or both, and received HBO2. Neuropsychiatric tests included EEG, mini-mental status examination (MMSE), brain MRI, event-related potential (ERP), and brain perfusion scan (brain SPECT). Results of these tests were compared before and after HBO2, and the clinical features were monitored during this period. RESULTS: The symptoms of DNS for all patients improved significantly after HBOT. Although white matter changes remained evident in the brain MRI scans, other examinations such as EEG, MMSE, ERP, and 99mTc-ECD brain SPECT were nearly normal after HBOT. CONCLUSION: Our results suggest that HBO2 decreases the severity of impairment in patients with DNS. Although a large randomized trial is required to address the efficacy of this therapy, therapeutic application of HBO2 may be recommended in patients with DNS after CO poisoning. en_US
dc.language.iso en en_US
dc.publisher Undersea and Hyperbaric Medical Society, Inc. en_US
dc.subject Carbon Monoxide Poisoning en_US
dc.subject MRI en_US
dc.subject.mesh Adult en_US
dc.subject.mesh Carbon Monoxide Poisoning/complications/diagnosis/*therapy en_US
dc.subject.mesh Dementia/etiology/therapy en_US
dc.subject.mesh Female en_US
dc.subject.mesh Humans en_US
dc.subject.mesh *Hyperbaric Oxygenation en_US
dc.subject.mesh Magnetic Resonance Imaging en_US
dc.subject.mesh Male en_US
dc.subject.mesh Mental Disorders/diagnosis/etiology/*therapy en_US
dc.subject.mesh Middle Aged en_US
dc.subject.mesh Movement Disorders/etiology/*therapy en_US
dc.subject.mesh Psychotic Disorders/etiology/therapy en_US
dc.subject.mesh Syndrome en_US
dc.title Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning. en_US
dc.type Article en_US

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