[abstract] LEBER'S OPTIC NEUROPATHY RESPONDS TO HBOT IN IDENTICAL TWINS

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[abstract] LEBER'S OPTIC NEUROPATHY RESPONDS TO HBOT IN IDENTICAL TWINS

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Title: [abstract] LEBER'S OPTIC NEUROPATHY RESPONDS TO HBOT IN IDENTICAL TWINS
Author: Spiegel, A
Abstract: Background: Leber's hereditary optic neuropathy is a rare disease of young men initiating from their early teens to early 20's, and characterized by an onset over a few weeks to months of painless, severe, central visual loss in one eye, progressing to involve the opposing eye weeks or months later by the same process. LHON is one of a group of mitochondrial diseases, that are inherited only through the mother. Mitochondria are the bodies within cells where energy needed for the activities of the cell is the factor that renders mitochondria in optic nerve cells unable to produce energy, thereby producing cell death, and are largely unknown. So far, no treatment has been proven effective in controlled trials for LHON. Materials and Methods: Identical twin brothers with progressive painless central visual field loss in 2002 were diagnosed as having Leber's hereditary optic neuropathy by their Neuroophthalmologist. One was rendered totally blind in 2006 while the other had complete loss of vision in the left eye and severe impairment on the right. September '06 through February of '07 the patient received 80 sessions of HBOT at 2.4 ATA 90 minute dives along with 600 mg glutathione administered intravenously three times a week while receiving HBOT. Results: Visual acuity on the left was 20/50 with ability to discern 7/10 color plates at the onset of the study. At the completion of hyperbaric therapy, visual acuity improved to 20/25 near vision with ability to discern 8/10 color plates. Two years following the last hyperbaric treatment vision remains 20/40 (corrected to 20/20 with contact lenses) and ability to discern 9/10 color plates. Right eye showed no response. There has been no regression of visual acuity in the past two years where no additional therapy has been provided. His brother, who did not receive HBOT, remains totally blind. Conclusion: This case study supports the belief that the neuroprotective effects of HBOT with Glutathione aids in preserving mitochondrial function and integrity in various ophthalmologic disorders such as Leber's Optic Neuropathy.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting, St Pete Beach, Florida, USA. (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/9286
Date: 2010

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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