A new method of measure of bubble gas volume shows that interleukin-6 injected into rats has no effect on gas embolism.

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A new method of measure of bubble gas volume shows that interleukin-6 injected into rats has no effect on gas embolism.

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dc.contributor.author Bondi, M
dc.contributor.author Cavaggioni, A
dc.contributor.author Gasperetti, A
dc.contributor.author Rubini, A
dc.date.accessioned 2010-03-30T17:33:16Z
dc.date.available 2010-03-30T17:33:16Z
dc.date.issued 2009
dc.identifier.citation Undersea Hyperb Med. 2009 Mar-Apr;36(2):103-15. en
dc.identifier.isbn 1066-2936
dc.identifier.other PMID: 19462750
dc.identifier.uri http://archive.rubicon-foundation.org/8367
dc.description ndersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc en
dc.description.abstract The pleiotropic cytokine interleukin-6 increases in the plasma of rats after an air dive. Interleukin-6 shares both of inflammatory and anti-inflammatory properties and may condition the vascular system and gas embolism after an air dive. Up to now it is not known whether interleukin-6 has an effect on gas embolism. Aim of this work is to study the effect of interleukin-6 on gas embolism after a standard decompression protocol in a rat model. The volume of gas bubbles was measured in the heart cavities with a new method based on the buoyancy of the heart at different pressures which is physically sound, accurate and precise down to 10(-4) cm3. No effect was found after injecting physiological doses of interleukin-6 at different times before the air dive. The mortality of the rats in the first half hour after the decompression was associated with a substantial gas volume measured in the heart. Multi-variate logistic regression analysis showed that the female rats had a higher risk compared to male rats of developing a substantial bubble volume and of not surviving; the spring-summer season was a risk factor for the survival. Further studies are needed to see whether interleukin-6 in association with other cytokines has an effect on gas embolism. en
dc.format.extent 1793318 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher Undersea and Hyperbaric Medical Society en
dc.subject Animals en
dc.subject Decompression Sickness/*prevention & control en
dc.subject Embolism, Air/*prevention & control en
dc.subject Female en
dc.subject Heart Diseases/*prevention & control en
dc.subject Injections, Intramuscular en
dc.subject Interleukin-6/administration & dosage/*pharmacology en
dc.subject Male en
dc.subject Organ Size en
dc.subject Rats en
dc.subject Rats, Wistar en
dc.subject Recombinant Proteins/administration & dosage/pharmacology en
dc.subject Regression Analysis en
dc.subject Sex Factors en
dc.title A new method of measure of bubble gas volume shows that interleukin-6 injected into rats has no effect on gas embolism. en
dc.type Article en

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