[abstract] THE EFFECT OF HYPERBARIC OXYGEN ON RADIATION SENSITIVITY IN SQUAMOUS CELL CARCINOMA

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[abstract] THE EFFECT OF HYPERBARIC OXYGEN ON RADIATION SENSITIVITY IN SQUAMOUS CELL CARCINOMA

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Title: [abstract] THE EFFECT OF HYPERBARIC OXYGEN ON RADIATION SENSITIVITY IN SQUAMOUS CELL CARCINOMA
Author: Zamboni, AC; Snyderman, CH
Abstract: The sensitivity of squamous cell carcinoma (SCC) to radiation therapy (XRT) may be related to the local oxygen tension in tumor tissues. Methods aimed at raising local oxygen tension in SCC may increase the oxygen free radical mediated tumoricidal effect associated with XRT. The purpose of this study was to investigate the effectiveness and timing of hyperbaric oxygen (HBO) used concurrently with XRT in a murine SCC model. C3H/HEJ mice were inoculated in the right flank with a murine SCC (5x10^6 SCC VII/SF cells sub q). All tumors were allowed to grow for 21 days prior to experimentation. The experimental groups consisted of: control (XRT alone), delayed HBO/XRT (HBO given 12 hours prior to XRT), and immediate HBO/XRT (HBO given < 5 minutes prior to XRT). HBO was delivered as 100% O2 at 2.4 ATA for 2 hours per treatment. All groups were treated with 700 rads every other day for three treatments. Tumor growth was monitored twice weekly. No XRT induced morbidity or mortality was encountered. Animals were sacrificed 15 days after the final XRT treatment. Immediate HBO/XRT was associated with a significant decrease in tumor growth (final tumor volumes: immediate HBO/XRT = 9.71 cm3 ± 3.88 cm3 vs. control = 13.08 cm3 ± 3.69 cm3, p<.05) and final tumor weight (immediate HBO/XRT = 10.05g ± 3.17 g vs. control = 12.88 g ± 3.29 g, p<.05) compared to controls. Delayed HBO/XRT was not associated with a statistical difference in tumor growth or final tumor weight compared to controls. Clinical studies have suggested improved local control of SCC of the head and neck when HBO was administered concurrently with XRT. The present study corroborates these clinical studies, using a controlled animal model. The timing of HBO administration appears to be critical in enhancing radio-sensitivity, suggesting that tumor oxygen dependent free radical production is responsible for the synergistic tumoricidal effect.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held July 7-10, 1993. World Trade and Convention Centre, Halifax, Nova Scotia, Canada. (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/8181
Date: 1993

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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