[abstract] OBSERVATION OF MICROCIRCULATION IN SPINAL DCS RATS CAUSED BY HELIUM MIXED GAS HYPERBARIC EXPOSURE AND THE EFFECT OF OXYGEN RECOMPRESSION.

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[abstract] OBSERVATION OF MICROCIRCULATION IN SPINAL DCS RATS CAUSED BY HELIUM MIXED GAS HYPERBARIC EXPOSURE AND THE EFFECT OF OXYGEN RECOMPRESSION.

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Title: [abstract] OBSERVATION OF MICROCIRCULATION IN SPINAL DCS RATS CAUSED BY HELIUM MIXED GAS HYPERBARIC EXPOSURE AND THE EFFECT OF OXYGEN RECOMPRESSION.
Author: Nodera, M; Gotoh, Y; Nashimoto, I
Abstract: INTRODUCTION: We have shown that a short and deep helium mixed gas (Heliox) hyperbaric exposure causes high risk of spinal decompression sickness (DCS) in rats (11th UJNR meeting, 1991). In the present study, we examined appearance of microcirculation bubbles in spinal DCS rats caused by Heliox hyperbaric exposure, and evaluated the effect of oxygen recompression treatment on paralyzed rats due to spinal DCS. METHODS: Experiment One: Rats (340-380 g) were exposed to 7 ATA Heliox (80/20) for 20 min. After surfacing, they were remained in the Heliox environment for 10 min to observe any symptoms. Rats who showed hind limb paralysis (n=5) were observed for adipose tissue of the epididymis and subcutaneous microcirculation using a microscopic high speed VTR system until 60 min after surfacing. Experiment Two: After repeating the same hyperbaric exposure as the Experiment One, rats showing limb paralysis (n=5) were recompressed to 3 ATA by 100% oxygen for 20 min. Ten min after a post-exposure observation period, they were examined for microcirculation bubbles using the same technique as in the Experiment One. RESULTS: The subcutaneous and epididymis adipose tissue in the paralyzed rats had extra-vascular bubbles in the whole microscopic vision area. Also, observed were abundant formation of micro-gas embolism in the subcutaneous venule. On the other hand, the paralyzed rats who received the oxygen recompression treatment showed no extra- and intra-vascular bubbles, although they had no improvement in paralytic state. CONCLUSION: From these results, it was suggested that oxygen recompression facilitate bubble disappearance after Heliox hyperbaric exposure but improve paralytic state caused by the exposure. Further study is needed for the lack of improvement in paralysis by oxygen recompression treatment.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held July 7-10, 1993. World Trade and Convention Centre, Halifax, Nova Scotia, Canada. (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/8170
Date: 1993

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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