[abstract] IMMERSION PRIOR TO DRY SIMULATED DIVE REDUCES HEART FUNCTION AND INCREASES MORTALITY AFTER DECOMPRESSION.

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[abstract] IMMERSION PRIOR TO DRY SIMULATED DIVE REDUCES HEART FUNCTION AND INCREASES MORTALITY AFTER DECOMPRESSION.

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Title: [abstract] IMMERSION PRIOR TO DRY SIMULATED DIVE REDUCES HEART FUNCTION AND INCREASES MORTALITY AFTER DECOMPRESSION.
Author: Gaustad, SE; Wisløff, U; Brubakk, AO
Abstract: INTRODUCTION: Diving and decompression performed under immersed conditions may lead to cardiac changes which are not present during dry hyperbaric exposures. However, the mechanisms behind these changes have not been elucidated. The goal of the present study was to examine the effects of immersion prior to a simulated hyperbaric dive. MATERIAL AND METHODS: A total of 23 adult female (285-310 g) Sprague-Dawley rats were randomly assigned into four groups; control, 1 h immersion, simulated dry dive and 1 h immersion prior to a simulated dive. Rats adapted to water underwent neck immersion for 1 h at a water temperature 34-37 ± 0.5 oC. Rats exposed to a simulated dive were compressed in a pressure chamber at a rate of 200 kPa min-1 to a pressure of 700 kPa, maintained for 45 min breathing air and decompressed linearly to the surface at a rate of 50 kPa min-1. Immediately after reaching the surface the animals were anaesthetised and the right ventricle was insonated using ultrasound. Removal of the heart and isolation of cardiomyocytes was performed immediately after completion of bubble detection. RESULTS: The study demonstrated that 1 h immersion prior to a simulated dive significantly decreased the survival time, and there was a trend towards higher bubble production in these rats. Furthermore, analysis of cardiomyocyte function showed depressed sarcomere properties and calcium handling during both systole and diastole in rats exposed to immersion prior to a dive. CONCLUSIONS: The present study is the first study to demonstrate that immersion prior to a dry simulated dive results in cellular cardiac function such as reduced contractility, diastolic relaxation, and calcium sensitivity with a subsequent reduction in survival time.
Description: Abstract of the Undersea & Hyperbaric Medical Society 2008 Annual Scientific Meeting June 26-28, 2008 Salt Lake City Marriott Downtown, Salt Lake City, Utah.
URI: http://archive.rubicon-foundation.org/7932
Date: 2008

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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