[abstract] DOES HBO PROMOTE NEOPLASIA IN CANCER SURVIVORS?

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[abstract] DOES HBO PROMOTE NEOPLASIA IN CANCER SURVIVORS?

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Title: [abstract] DOES HBO PROMOTE NEOPLASIA IN CANCER SURVIVORS?
Author: Capelli-Schellpfeffer, M; Stenson, K; Karczewski, D; Curtis, S
Abstract: BACKGROUND: We present a review of our clinical experience (1992-1998) to address the question of whether head and neck cancer patients receiving HBO have a higher rate of recurrence or cancer related death. In the treatment of radiation tissue necrosis or complicated open wounds, the role of HBO in promoting cancer recurrence is often questioned by patients, their families and referring clinicians. The emergence of angio-statins as possible anti-cancer agents has drawn attention to the oxygen-dependent behavior of certain tumors. The literature suggests that HBO does not promote cancer growth 1,2, however new insights regarding the role of angiogenesis in the growth tumors3 may influence how this potential risk of HBO is understood. METHODS: A descriptive retrospective study of 14 patients and literature review regarding oxygen homeostasis and tumorgenesis. RESULTS: The cases of 5 women and 9 men were reviewed, average age 59 years with average follow-up from diagnosis date to review of 37 months. Radiation therapy received was average 707s Gy. Median number of monoplace HBO treatments was 20 (at 90') at 2.5 ata. No new tumors were diagnosed. Four patients expired in the study period, (with tumor grades T4N2M0, T4N2aM0, T4N2bM0, T3-4N1M4); 1-recurrence, 1-carotid blow-out, 1-chronic illness-related and 1-undetermined cause. CONCLUSIONS: Our clinical results of patients receiving HBO do not suggest inhancement of tumor recurrence or a change in the mortality trend. From the molecular biology literature, a number of adaptive responses to hypoxia are understood at the molecular level to involve transcriptional activation of gene expression by HIF-14. To address the question of whether HBO may promote neoplasia, new knowledge is needed regarding the rold of periodic hyperoxia in modulating the expression if hypoxia-inducible factor 1(HIF-1) in affected tissue. References: 1. Bevers RFM, Bakker DJ, Kurth KH. 1995.Lancet. 346:803-805. 2. Feldmeier JJ, Heimbach RD, Davolt DA, Brakora MJ, Sheffield PJ, Porter AT. 1994. Undersea and Hyperbaric Medicine. 23:467. 3. Rowe PM. 1998 Lancet. 349 (9045):108 4.Iyer NV, Kotch LE, Agani F, et al. 1998. Genes and Development. 12:149-162.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/793
Date: 1999

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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