[abstract] OXYGEN RESERVOIR DRESSING SUSTAINS ELEVATED WOUND OXYGEN TENSION AFTER HYPERBARIC OXYGEN TREATMENT.

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[abstract] OXYGEN RESERVOIR DRESSING SUSTAINS ELEVATED WOUND OXYGEN TENSION AFTER HYPERBARIC OXYGEN TREATMENT.

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Title: [abstract] OXYGEN RESERVOIR DRESSING SUSTAINS ELEVATED WOUND OXYGEN TENSION AFTER HYPERBARIC OXYGEN TREATMENT.
Author: Hopf, HW; Mulder, G; Duchnick, J
Abstract: BACKGROUND: The benefits of hyperbaric oxygen therapy (HBOT) for wound healing are well established result from the oxidant effects of oxygen and biologic processes for which oxygen is a rate-limiting step. Although the major benefits of HBOT clearly result from systemic oxygen delivery, the potential benefits of topical oxygen are also of interest. We therefore evaluated an oxygen reservoir dressing (OxyBandTM) for its ability to maintain elevated levels of dissolved oxygen (PO2) in wounds after HBOT. Oxygen delivery by the dressing is diffusion driven, saturating wound fluid and then replacing oxygen as it is consumed using a bi-layer reservoir that stores oxygen gas between a high transmission rate film over the wound and an occlusive film. METHODS: With IACUC approval, 8 standardized full thickness wounds were created on the back of 2 pigs (one control, one HBOT). The wounds were covered with either thin film (4 per pig) or OxyBandTM (4 per pig) dressings. Oxygen levels at 2mm depth within the wound exudate were measured 3, 8, 11.5, 14, and 16 hours after dressing placement and 15 min, 2, 6, and 12 hours after HBOT using polarographic microelectrodes. RESULTS: With the pigs intubated and anesthetized (FiO2 1.0), the PO2 ranged from 81-106 mmHg under the control bandage and 160-228 mm Hg under the test bandage. PO2 was 256-260 mmHg under both dressings 15 min after HBOT. At 2-12 hours after HBOT, PO2 was 89-125 mmHg under the control bandage and 245-263 mmHg under the test bandage. CONCLUSIONS: The OxyBandTM reservoir dressing maintained elevated wound oxygen levels after HBOT, demonstrating that the dressing was able to replenish oxygen levels as it was consumed locally. Potential synergies of providing the systemic benefits of HBOT and extending the local benefits of hyperoxia using an on-demand oxygen reservoir dressing warrants further investigation.
Description: Abstract of the Undersea & Hyperbaric Medical Society 2008 Annual Scientific Meeting June 26-28, 2008 Salt Lake City Marriott Downtown, Salt Lake City, Utah.
URI: http://archive.rubicon-foundation.org/7864
Date: 2008

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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