[abstract] MEAN PtcO2 VALUES AS AN OUTCOME PREDICTOR IN HYPERBARIC OXYGEN TREATMENT OF HYPOXIC WOUNDS.

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[abstract] MEAN PtcO2 VALUES AS AN OUTCOME PREDICTOR IN HYPERBARIC OXYGEN TREATMENT OF HYPOXIC WOUNDS.

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Title: [abstract] MEAN PtcO2 VALUES AS AN OUTCOME PREDICTOR IN HYPERBARIC OXYGEN TREATMENT OF HYPOXIC WOUNDS.
Author: Sheffield, PJ; Dietz, D; Posey, KI; Sheffield, JC; Bakken, B
Abstract: INTRODUCTION: At the Nix Wound Healing Center, transcutaneous oximetry (TC) is used to assess problem wound patients for hyperbaric oxygen (HBO2) therapy. This prospective study evaluates wound healing outcomes to assess reliability of mean PtcO2 values in selecting HBO2 candidates. MATERIALS AND METHODS: Standard TC tests were conducted at 1 ATA with 20-min respired air, 5-min leg elevation, and 10-min oxygen provocation. Patients breathed air (TC-Air) to determine baseline PtcO2 followed by 100% oxygen administered via oxygen hood (TC-O2). Mean PtcO2 values were computed from 2 adjacent sites proximal to the wound that were collected simultaneously. Mean PtcO2 values were used to assign patients to one of three treatment groups: Wound Care, HBO2, or Surgery. The PtcO2 parameter that predicted healing without HBO2 (TC-Air) was: TC-Air >40 mmHg. PtcO2 parameters that predicted healing with HBO2 (TC-Test) were: TC-Air <40 mmHg; TC-O2 >35 mmHg; and TC-%Rise >50%. RESULTS: Total outcomes (n=114) obtained for three treatment groups were: Wound care only (n=32), surgical remedy only (n=37), and HBO2 plus surgery and/or wound care (n=45). Mean PtcO2 values correctly predicted healing in 73 of 79 (92%) and correctly predicted non-healing in 27 of 35 (77%), with 88% reliability. In the HBO2 plus surgery and/or wound care group (n=45), mean PtcO2 values correctly predicted healing in 27 of 30 (90%) and correctly predicted non-healing in 9 of 15 (60%), with 80% reliability. CONCLUSIONS: Suggested parameters for predicting healing with HBO2 were: TC-Air <40 mmHg; TC-O2 >35 mmHg; and TC-%Rise >50%. For HBO2 treated patients, diagnostic tests resulted in sensitivity (ability to predict healing) of 90% and specificity (ability to predict non-healing) of 60%, with 80% reliability. These parameters and data suggest that mean PtcO2 values from 1 ATA TC-Test is an appropriate method for selecting HBO2 patients.
Description: Abstract of the Undersea & Hyperbaric Medical Society 2008 Annual Scientific Meeting June 26-28, 2008 Salt Lake City Marriott Downtown, Salt Lake City, Utah.
URI: http://archive.rubicon-foundation.org/7853
Date: 2008

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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