[abstract] PULMONARY EDEMA WITH VENOUS GAS EMBOLI: NO EVIDENCE FOR MICROVASCULAR PERMEABILITY CHANGE.

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[abstract] PULMONARY EDEMA WITH VENOUS GAS EMBOLI: NO EVIDENCE FOR MICROVASCULAR PERMEABILITY CHANGE.

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Title: [abstract] PULMONARY EDEMA WITH VENOUS GAS EMBOLI: NO EVIDENCE FOR MICROVASCULAR PERMEABILITY CHANGE.
Author: Butler, BD; Allen, SJ; Laine, GA
Abstract: Venous gas emboli (VGE) can result in pulmonary hypertension "chokes" and pulmonary edema. Some studies suggest that the edema formation is a result of VGE causing a change in lung microvascular permeability. Anesthetized dogs received VGE while measuring pulmonary artery pressure (PAP), left atrial pressure (LAP), central venous pressure (CVP) , tracheobronchial lymph flow (QL) and lymph to plasma protein concentration ratio (CL/CP). In one group of dogs QL was measured with the cannula open to the atmosphere or connected to the CVP catheter. In these animals changes in QL were determined with normal CVP and with elevated CVP resulting from increased VGE. In those dogs with no increase in CVP, QL increased regardless of whether the cannula flowed against atmospheric or central venous pressure and CL/CP was unchanged. When CVP was increased by additional VGE, QL decreased yet CL/CP remained unchanged. In another group of dogs LAP was increased to 30 mmHg using a balloon catheter to increase QL such that CL/CP reached filtration independence. VGE were then infused at 0.14 ml·kg-1·min-1 for 120 min. An increase in CL/CP would indicate an increase in lung microvascular permeability. When CL/CP was decreased by increasing LAP to filtration independence, no change in CL/CP occurred after VGE. At these high QL's an insult that causes an increase in microvascular permeability would cause a change in the filtration independent point and thus increase CL/CP. We found an increase in PAP and CVP but no change in microvascular permeability associated with VGE. This suggests that pulmonary edema associated with VGE is likely to be due to increases in microvascular pressure.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Joint Annual Scientific Meeting with the International Congress for Hyperbaric Medicine and the European Undersea Biomedical Society held 11-18 August 1990. Okura Hotel, Amsterdam, The Netherlands (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/7085
Date: 1990

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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