[abstract] A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED, MULTICENTRIC, CLINICAL TRIAL ASSESSING THE EFFECTS OF HYPERBARIC OXYGEN THERAPY ON CEREBRAL PALSY.

Rubicon Research Repository/Manakin Repository

[abstract] A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED, MULTICENTRIC, CLINICAL TRIAL ASSESSING THE EFFECTS OF HYPERBARIC OXYGEN THERAPY ON CEREBRAL PALSY.

Show full item record


Title: [abstract] A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED, MULTICENTRIC, CLINICAL TRIAL ASSESSING THE EFFECTS OF HYPERBARIC OXYGEN THERAPY ON CEREBRAL PALSY.
Author: Tremblay, SD; Vanasse, M; Amar, M; Marois, P; Goldberg, J; Dugas, M; Côté, M; Montgomery, D; Lambert, J; Lassonde, M; Fortin, J; Robinson, A; Lacroix, V; Lacroix, J; Rosenblat, B; Sylvain, M; Collet, J-P
Abstract: BACKGROUND: Casual unpublished reports from several centres in UK and the US suggest that HBO therapy may improve the medical condition of patients with cerebral palsy (CP). However, because of selection bias and lack of controlled design these observations are not sufficient to establish the beneficial effect of HBO therapy. The main objective of this double blind RCT is to measure in a systematic matter the effect of HBO therapy on gross motor function in CP patients. Secondary objectives include measurements of the effect of HBO on fine motor function, spasticity, attention, memory, speech and language. METHODS: The study is a double blind, multicentric, placebo controlled, clinical trial. A total of 112 CP patients aged 3 to 12 years old with diplegic, quadriplegic or double hemiplegic encephalopathy are randomly allocated to experimental and placebo group. Both groups receive a total of 40 treatments (once a day, 5 days a week for 8 consecutive weeks). The experimental group is treated with 100% oxygen at 1.75 ATA for 1 hr. while patients allocated to placebo is treated with air at 1.30 ATA for 1 hr. Evaluation of gross and fine motor function is conducted prior to, at mid-point (after 20 sessions) and at the end of the treatment regimen. Another evaluation may be conducted 3 months post treatment if a positive effect is observed at the end of the 40 sessions. Gross motor function is assessed using the Gross Motor Function Measurement test (GMFM) and fine motor function with the Jebsen test. Secondary outcomes include: spasticity, attention, memory, speech and language, as well as parent's assessment (PEDI). All evaluations are standardised and conducted by specialists who are blind from the treatment administered. Side effects are monitored systematically. RESULTS: Statistical analysis will be performed after completion of the intervention for the last child included (mid-January 2000). Preliminary results will be available for presentation during the UHMS scientific meeting.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/6935
Date: 2000

Files in this item

Files Size Format View
abstract.txt 193bytes Text file View/Open

This item appears in the following Collection(s)

  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

Show full item record

Browse

My Account