[abstract] DOSE-RESPONSE FOR HYPERBARIC OXYGEN TREATMENT OF RADIATION CYSTITIS (RC).

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[abstract] DOSE-RESPONSE FOR HYPERBARIC OXYGEN TREATMENT OF RADIATION CYSTITIS (RC).

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Title: [abstract] DOSE-RESPONSE FOR HYPERBARIC OXYGEN TREATMENT OF RADIATION CYSTITIS (RC).
Author: Hendricks, DM; Kraft, KL; Moon, RE; Piantadosi, CA; Stolp, BW
Abstract: BACKGROUND: The optimum protocol for HBO treatment of RC is not yet established. METHODS: A total of 20 patients (mean age 72.2 years) with cystoscopically or biopsy demonstrated RC, who had failed other treatment modalities, received HBO treatment (2 ATA/2h, 2 x daily, 5-6 days/week) from July 1993 to October 1999 at Duke Medical Center. Mean number of treatments was 35.6 and treatment days was 21.7. Follow-up ranged from 2 to 30 months (mean 13 months). These data were then combined with published observations from 6 other institutions (135 patients) to examine effects of daily O2 dose, number of treatment days, and concentration-time product (ATA x time x mean treatments). RESULTS: Hematuria resolved completely in 14 of 20 patients (70%) in our series (mean 34.2 treatments). Six patients failed to resolve (mean 38.7 treatments) and required surgical intervention. This response rate was comparable to results obtained from previous studies at similar follow-up times. Examination of the pooled data revealed that the resolution rate was correlated with the number of treatment days (P=0.4) and concentration-time product (P=0.2), but not the daily dose of oxygen. (Graphs on page 39 of supplement.) CONCLUSIONS: These findings strongly suggest that both total oxygen dose and duration of treatment affect the resolution of RC. Because the two variables were highly correlated, their independent effects cannot be established from these data. Generally, optimal results appear to occur at oxygen doses of >100 ATA-hours O2 and 40 treatment days.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/6645
Date: 2000

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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