[abstract] IDENTIFICATION OF THE EARLY TIME WINDOW POST STROKE FOR HYPERBARIC OXYGEN EFFICACY IN THE TREATMENT OF ACUTE STROKE: A RETROSPECTIVE STATISTICAL ANALYSIS.

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[abstract] IDENTIFICATION OF THE EARLY TIME WINDOW POST STROKE FOR HYPERBARIC OXYGEN EFFICACY IN THE TREATMENT OF ACUTE STROKE: A RETROSPECTIVE STATISTICAL ANALYSIS.

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Title: [abstract] IDENTIFICATION OF THE EARLY TIME WINDOW POST STROKE FOR HYPERBARIC OXYGEN EFFICACY IN THE TREATMENT OF ACUTE STROKE: A RETROSPECTIVE STATISTICAL ANALYSIS.
Author: McCormick, JG; Houle, TT; Saltzman, HA; Whaley, RC; Roy, RC
Abstract: BACKGROUND: FDA approved treatment for acute stroke is IV Tissue Plasminogen Activator (rt-PA) within 3 hours post stroke. Rusyniak, et al. (1) and Nighoghossian, et al. (2) examine Hyperbaric Oxygen (HBO2) treatment for acute stroke in the 5 to 24 hour period post stroke with non-conclusive efficacy. To compare the efficacy of HBO2 for treatment of acute stroke in an earlier time window, we conducted a retrospective statistical analysis of the Heyman, Saltzman, Whalen (3) study of 22 HBO2 treated stroke patients with 13 patients in the 1 to 5 hour post stroke category. Stroke improvement found occurred within minutes of HBO2 application--never longer than 30 minutes. MATERIALS AND METHODS: For our analysis we examined those patients who received HBO2 treatment (3) within 7 hours post stroke. An exploratory logistic regression analysis examining the influence of time-post-stroke, time-in-chamber, and dose of HBO2 (range 2.02 ata to 3.04 ata) was conducted. RESULTS: Only time-post-stroke was a significant influence for recovery, with each passing hour decreasing the chance of at least partial transient recovery by 62%, Odds Ratio: 0.38 (95% CI: 0.15 - 0.95), p = 0.039. In the 1 to 5 hour group of 13 patients, 9 (41% of 22) had recovery or recovery with relapse. This represented 69% (+/- 25% SE) of this time frame. Only 2 of the 9 had permanent recovery. Past 6 hours post stroke, only 1 patient (11% +/- 21% SE) had partial recovery with relapse. The other 8 past 6 hours had no recovery at all. CONCLUSIONS: A multi-center randomized controlled study of HBO2 treatment of acute stroke is needed. First 3 hours post stroke HBO2 administration has the most promise for efficacy and improvement of tPA therapy. HBO2 may also prove to be a useful challenge pre-tPA administration to assess the risk benefit ratio for giving tPA. REFERENCES: 1) Rusyniak DE, et al. STROKE 34:571-574. 2003. 2) Nighoghossian N, et al. STROKE 26:1369-1372. 1995. 3) Heyman A, et al. CIRCULATION 33&34:II20-II27. 1966.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held June 14-16, 2007. Ritz-Carlton Kapalua Maui, Hawaii (http:www.uhms.org)
URI: http://archive.rubicon-foundation.org/5220
Date: 2007

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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