[abstract] THE INFLUENCE OF IBUPROFEN, PGI2 AND HEPARIN ON EVOKED RESPONSE RECOVERY AFTER AIR EMBOLISM.

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[abstract] THE INFLUENCE OF IBUPROFEN, PGI2 AND HEPARIN ON EVOKED RESPONSE RECOVERY AFTER AIR EMBOLISM.

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Title: [abstract] THE INFLUENCE OF IBUPROFEN, PGI2 AND HEPARIN ON EVOKED RESPONSE RECOVERY AFTER AIR EMBOLISM.
Author: Hallenbeck, JM; Greenbaum Jr, LJ; Leitch, DR
Abstract: Temporary arrest of central nervous system (CNS) blood flow for long enough to cause some tissue damage results in focal areas of increased resistance to microcirculatory perfusion when blood flow is restored, a circumstance for which the term "no-reflow phenomenon" has been employed. We have proposed that this focal increase in resistance to nutrient blood flow depends upon an interaction between blood and damaged tissue (Neurology 27:3-10, 1977) and have demonstrated that activity deleterious to reperfusion resides in the cryoprecipitate fraction of autologous plasma (Stroke 9:375-382, 1978). Related studies have shown that the prostaglandin system with its blood-borne (platelet-bound) and endothelial cell-bound components is involved in the "noreflow phenomenon" (Stroke 9:591-594, 1978). The current work investigates the therapeutic potential of a stable analogue of PGI2 in combination with the cyclooxygenase inhibitor, Ibuprofen and heparin. Suppression of the sensory evoked response (SER) is maintained for 1 hour by delivering 20-50 ul quantities of air incrementally into the internal carotid artery as required. Following 1 hour of ischemic suppression of the SER, a 60 minute recovery period is permitted. The extent of neuronal recovery in control and treated groups is assessed by the degree t o which the SER is restored toward baseline amplitude. At the conclusion of the recovery period a 14C-iodoantipyrine autoradiographic blood flow study is performed. Comparison of treated and untreated groups indicates that drugs significantly enhanced both SER recovery and postischemic CNS blood flow. These agents may offer a novel therapeutic approach in ischemic CNS disorders such as air embolism and cord-damaging decompression sickness.
URI: http://archive.rubicon-foundation.org/4716
Date: 1979

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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