[abstract] THREE DIMENSIONAL AND QUANTITATIVE IMAGE ANALYSIS OF NEUROPATHOLOGICAL CHANGES FOLLOWING CARBON MONOXIDE POISONING

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[abstract] THREE DIMENSIONAL AND QUANTITATIVE IMAGE ANALYSIS OF NEUROPATHOLOGICAL CHANGES FOLLOWING CARBON MONOXIDE POISONING

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Title: [abstract] THREE DIMENSIONAL AND QUANTITATIVE IMAGE ANALYSIS OF NEUROPATHOLOGICAL CHANGES FOLLOWING CARBON MONOXIDE POISONING
Author: Hopkins, RO; Weaver, LK; Gale, SD; Johnson, SC; Bigler, ED; Blatter, DD; Abidlskov, TJ
Abstract: BACKGROUND: Prior research has demonstrated that carbon monoxide (CO) poisoning can cause a variety of neuropsychological and neuropathological changes. Morphology typically involved the basal ganglia, white matter, and hippocampus. Pracyk (1995) showed that 40percent of patients with CO poisoning who lose consciousness have changes on brain CT scans. Recent advances in magnetic resonance imaging (MRI) permits quantification of a variety of neuroanatomical structures using two-dimensional (2D) images. In conjunction with the two-dimensional quantification, 3D image analysis provides the means by which neuroanatomical structures can be isolated and examined in three dimensions. METHODS: Seven patients (4 males, 3 females) with CO poisoning, all treated with hyperbaric oxygen, received MRI scans and a comprehensive neuropsychological battery. Subjects were evaluated 5 months to 3 years post poisoning. The tests included: Weschler Adult Intelligence Scale-Revised, Weschler Memory Scale-Revised, Wide Range Achievement Test, Rey Auditory-Verbal Learning Test, Trails AandB, and Rey-Osterrieth Complex Figure. Quantitative analysis of MR scans were carried out using ANALYZE (Biomedical Imaging Resource, Mayo Foundation, Rochester, MN) and IMAGE (Wayne Rasband, NIH). Volumetric Measurements included: CSF, ventricle size, gray matter, white matter, and ventricle-brain ratio. Measurements were corrected for head size and compared to normative MRI age and gender matched controls (Blatter, 1995). RESULTS: The neuropsychological results show the following impairments: 6 patients experienced verbal and visual memory, 4 with impaired verbal learning, 4 with problems with attention/concentration, and 2 with problems with speed of processing impairments. The Quantitative MR results are only considered significant if the data is greater than or less than 1 SD. The Quantitative results are as follows: 3 patients had increased CSF, 1 with increased subarachnoid CSF, 3 with increased right and left temporal horns, 4 with enlarged lateral ventricles, 3 had an increase in total ventricle volume and 4 patients demonstrated increased ventricle-to-brain ratios. Two of the patients had normal brains as measured quantitatively. CONCLUSION: Of the 7 selected CO poisoned patients, 6 had cognitive abnormalities of which 5 had quantifiable neuroanatomical abnormalities (2D) which are visible following 3D reconstruction of the brains. CO poisoning may cause a variety of cognitive impairments, especially memory impairments. Quantitative MRI analysis revealed nonspecific neuropathological effects. Increased VBR indicates diffuse nonspecific neuroanatomical atrophy. The use of 3D MRI techniques provide visualization of the pathologic changes which occur following neural injuries. Currently these techniques are being used as research tools, their clinical applications remain to be determined.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/449
Date: 1996

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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