[abstract] PAROTID FLUID GAS TENSIONS AS AN INDEX OF TISSUE GAS TENSIONS.

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[abstract] PAROTID FLUID GAS TENSIONS AS AN INDEX OF TISSUE GAS TENSIONS.

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Title: [abstract] PAROTID FLUID GAS TENSIONS AS AN INDEX OF TISSUE GAS TENSIONS.
Author: Miller, DA; Styer, DJ; Messier, AA; Gilman, SC; Bondi, KR
Abstract: Due to the inaccessibility of the tissue compartment, techniques for measuring tissue gas tensions are invasive, which restricts routine use, and typically involve some disturbance of the tissue in the process of making the measurement. On the assumption that gas tensions in secretions should reflect those in the parent tissue, gas tensions in an externally accessible secretion are proposed as an indirect, noninvasive measure of gas tensions in an undisturbed tissue. To this end, studies were undertaken of gas tensions in human parotid fluid. Parotid secretion was elicited with sour grape candy, collected with a suction mounted, bubble free, plastic collector, and delivered "on-line" to a blood gas analyzer by means of a glass tube. With this arrangement, the existence of steady state gas tensions was confirmed prior to making stop flow measurements. In vitro tests established the absence of changes in gas tensions during collector transit. In 39 measurements with 8 adult male subjects, steady state gas tensions (x +/- sigma, range of means) was Po2 = 21.6 +/- 3.6 (17.9-23.3) mm Hg and Pco2 = 48.7 +/- 2.7 (44.5-52.2) mm Hg. With respect to individual measurements, the mean sigma and the range of values for O2 and CO2 were 4.2 (10.5-28.9) mm Hg and 1.9 (42.5-56.3) mm Hg respectively; the slope of the O2-CO2 relation was -0.2. A literature search revealed that the mean values are consistent with data obtained by invasive techniques in most tissues, and that the slope approximates that found in muscle. It is concluded that parotid fluid gas tensions have the characteristics of tissue fluids in most tissues, and therefore hold promise as a new, noninvasive index of gas tensions in the average undisturbed tissue. Potential uses are envisioned in respiratory and hyperbaric physiology and in clinical practice.
URI: http://archive.rubicon-foundation.org/4321
Date: 1978

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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