Incidence of Decompression Sickness in Mice as a Function of the Relative Concentrations of Helium and Nitrogen in the Inspired Gas Mixture.

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Incidence of Decompression Sickness in Mice as a Function of the Relative Concentrations of Helium and Nitrogen in the Inspired Gas Mixture.

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dc.contributor.author Wex, TG
dc.contributor.author Long, DG
dc.contributor.author Flynn, ET
dc.date.accessioned 2007-01-02T18:01:22Z
dc.date.available 2007-01-02T18:01:22Z
dc.date.issued 1971
dc.identifier.citation AD0738437 en
dc.identifier.govdoc AD0738437
dc.identifier.govdoc NEDU-RR-11-71
dc.identifier.uri http://archive.rubicon-foundation.org/3981
dc.description Citation Status: Active; Citation Classification: Unclassified; Title Classification: Unclassified; Report Classification: Unclassified; Identifier Classification: Unclassified; Abstract Classification: Unclassified; Distribution Limitation(s): 01 - APPROVED FOR PUBLIC RELEASE; Information provided by the Department of Defense and the Defense Technical Information Center (http://www.dtic.mil/) is considered public information and may be distributed or copied unless otherwise specified. Use of appropriate byline/photo/image credits is requested. en
dc.description.abstract Two hundred fifty mice were exposed to a pressure equivalent to 400 feet of seawater for 30 minutes while breathing a mixture of 2.09 - 2.33% oxygen and either (1) 97.8% N2, (2) 73.0% N2 24.6% He, (3) 48.7% N2 49.1% He, (4) 23.7% N2 74.2% He, or (5) 97.8% He. In each case, decompression to sea level followed an exponential course and was 90% complete in approximately 8 sec. The incidence of decompression sickness, as manifested by hind limb paralysis, convulsions and death, was found to vary with the relative proportions of helium and nitrogen in the inspired gas mixture. The greatest incidence was observed with the mixture containing nitrogen alone; the least with the mixture having equal proportions of nitrogen and helium in the inert gas fraction. Statistically, the bends incidence with all four mixtures containing helium was significantly lower (P<.001) than the bends incidence with the mixture containing only nitrogen. The differences in bends incidence between the mixtures containing helium, however, were not statistically significant. (Author) en
dc.description.sponsorship US NAVY en
dc.format.extent 1868791 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US en
dc.publisher NAVY EXPERIMENTAL DIVING UNIT WASHINGTON D C en
dc.subject decompression sickness en
dc.subject nitrogen en
dc.subject helium en
dc.subject DCS en
dc.subject PRESSURE en
dc.subject heliox en
dc.subject nitrox en
dc.subject air en
dc.subject trimix en
dc.subject HYPERBARIC CONDITIONS en
dc.subject hyperbaric medicine en
dc.title Incidence of Decompression Sickness in Mice as a Function of the Relative Concentrations of Helium and Nitrogen in the Inspired Gas Mixture. en
dc.type Technical Report en

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