Incidence of Decompression Sickness in Mice as a Function of the Relative Concentrations of Helium and Nitrogen in the Inspired Gas Mixture.

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Incidence of Decompression Sickness in Mice as a Function of the Relative Concentrations of Helium and Nitrogen in the Inspired Gas Mixture.

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Title: Incidence of Decompression Sickness in Mice as a Function of the Relative Concentrations of Helium and Nitrogen in the Inspired Gas Mixture.
Author: Wex, TG; Long, DG; Flynn, ET
Abstract: Two hundred fifty mice were exposed to a pressure equivalent to 400 feet of seawater for 30 minutes while breathing a mixture of 2.09 - 2.33% oxygen and either (1) 97.8% N2, (2) 73.0% N2 24.6% He, (3) 48.7% N2 49.1% He, (4) 23.7% N2 74.2% He, or (5) 97.8% He. In each case, decompression to sea level followed an exponential course and was 90% complete in approximately 8 sec. The incidence of decompression sickness, as manifested by hind limb paralysis, convulsions and death, was found to vary with the relative proportions of helium and nitrogen in the inspired gas mixture. The greatest incidence was observed with the mixture containing nitrogen alone; the least with the mixture having equal proportions of nitrogen and helium in the inert gas fraction. Statistically, the bends incidence with all four mixtures containing helium was significantly lower (P<.001) than the bends incidence with the mixture containing only nitrogen. The differences in bends incidence between the mixtures containing helium, however, were not statistically significant. (Author)
Description: Citation Status: Active; Citation Classification: Unclassified; Title Classification: Unclassified; Report Classification: Unclassified; Identifier Classification: Unclassified; Abstract Classification: Unclassified; Distribution Limitation(s): 01 - APPROVED FOR PUBLIC RELEASE; Information provided by the Department of Defense and the Defense Technical Information Center (http://www.dtic.mil/) is considered public information and may be distributed or copied unless otherwise specified. Use of appropriate byline/photo/image credits is requested.
URI: http://archive.rubicon-foundation.org/3981
Date: 1971

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