[abstract] IMMUNO-COMPETENT CELL POPULATION IS AFFECTED BY HYPERBARIC OXYGENATION

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[abstract] IMMUNO-COMPETENT CELL POPULATION IS AFFECTED BY HYPERBARIC OXYGENATION

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Title: [abstract] IMMUNO-COMPETENT CELL POPULATION IS AFFECTED BY HYPERBARIC OXYGENATION
Author: Hipp, R; Mielke, L; Salch, MA; Pildner, R; Lanzinger, MJ; Schleicher, P; Kling, M; Entholzner, E; Breinbauer, B; Hargasser, S
Abstract: BACKGROUND: Immuno-compromised patients with crush injuries, osteomyelitis, gas gangrene and other necrotizing infections, burn injuries, etc. are treated with HBO. The aim of the study was to evaluate the effect of HBO on immuno-competent cells. METHODS: After IRB approval and informed consent, 31 patients (both sexes, age greater than 18 yrs, no drugs like steroids or antibiotics) with inner ear problems were included in the investigation in a consecutive manner. They were treated with HBO: 100percent O2, 2.5 ATA., 110 min, once a day on 10 consecutive days. Venous blood samples were taken before the 1st and after the 10th treatment. T-lymphocytes, B-lymphocytes, suppressor/cytotoxic cells, helper cells, and natural killer cells were measured by flow cytometry using a FACS 420, FACS Scan (Becton Dickinson FACS Division, Sunnyvale, CA). Results were statistically evaluated by paired t-test, p less than 0.05 was considered significant. RESULTS: 31 non-ICU patients (42+/-12 yr; 176+/-8 cm; 76+/-13 kg; female: 11, male: 20) were included in the study. We found statistically significant changes in the lymphocyte population (percent of lymphocytes, median, min-max, before HBO/after 10 x HBO): T-lymphocytes (69, 50-81/71, 62/83) B-lymphocytes (10, 4-20/11, 5-19), suppressor/cytotoxic cells (36, 25-60/33, 25-54), helper cells (46, 29-66/50, 34-63) natural killer (NK) cells (20, 8-43/15, 7-31). CONCLUSION: HBO treatment on 10 consecutive days according to our treatment schedule showed effects on immuno-competent cell population in our patient population. Therefore, the effect of HBO on severe immuno-compromised patients like critical care patients should be investigated. In addition the effect of the HBO on the activity of the lymphocytes and natural killer cells, should be evaluated.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/395
Date: 1997

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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