[abstract] CENTRAL NERVOUS SYSTEM SOFT TISSUE RADIONECROSIS AND MAGNETIC RESONANCE IMAGES

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[abstract] CENTRAL NERVOUS SYSTEM SOFT TISSUE RADIONECROSIS AND MAGNETIC RESONANCE IMAGES

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dc.contributor.author Kelly, MP en_US
dc.contributor.author Glover, NR en_US
dc.contributor.author Cianci, PE en_US
dc.date.accessioned 2006-09-22T21:22:33Z
dc.date.available 2006-09-22T21:22:33Z
dc.date.issued 2006 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/3697
dc.description Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.description.abstract BACKGROUND: Hyperbaric oxygen (HBO) is utilized in the treatment of delayed radiation injuries. Magnetic resonance imaging (MRI) can detect abnormalities found with radiation injuries to the central nervous system (CNS). We present a case of CNS STRN responsive to HBO documented by improved subjective symptoms, physical exam findings, and MRCASE REPORT: A previously healthy 28 year-old male presented with new onset grand mal seizures and dystaxia was diagnosed with a left-sided oligodendroglioma in Nov 2003. The patient underwent surgery and adjunctive radiation treatment. Several months later the patient experienced symptoms consistent with delayed radiation injury. The patient demonstrated poor memory, change in personality, left foot drop, left foot clonus, dystaxia, depressed left sided proprioreception, and proximal left leg weakness. MRI showed significant areas of necrosis and edema to the right frontal area that corresponded with physical exam findings. The patient underwent 40 HBO treatments at 2 atmospheres, for 2 hourRESULTS: Post treatment re-evaluation revealed a dramatic reversal of the physical examination abnormalities and symptomatic improvement with memory and personality. MRI performed 3 weeks after completion of HBO demonstrated significant reduction in edema/inflammation of the right pre-frontal cortex. These changes are felt to clinically correlate with the patient's subsequent improvement.CONSLUSIONS: HBO is documented to reduce edema in damaged tissues through hyperoxic vasoconstriction and reverse radiation necrosis and edema by salvaging damaged, dormant tissue with the stimulation of angiogenesis. These processes lead to the restoration of normal tissue function and the arrest of progressive delayed radiation injury. HBOT can be dramatically helpful in the treatment of clinically significant cases of CNS STRN associated with edema following radiotherapy. MRI can readily document the beneficial effect of HBO. en_US
dc.language.iso en_US
dc.rights Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.subject HBO en_US
dc.subject radionecrosis en_US
dc.subject radiation en_US
dc.subject hyperbaric en_US
dc.title [abstract] CENTRAL NERVOUS SYSTEM SOFT TISSUE RADIONECROSIS AND MAGNETIC RESONANCE IMAGES en_US

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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