[abstract] CENTRAL NERVOUS SYSTEM SOFT TISSUE RADIONECROSIS AND MAGNETIC RESONANCE IMAGES

Rubicon Research Repository/Manakin Repository

[abstract] CENTRAL NERVOUS SYSTEM SOFT TISSUE RADIONECROSIS AND MAGNETIC RESONANCE IMAGES

Show full item record


Title: [abstract] CENTRAL NERVOUS SYSTEM SOFT TISSUE RADIONECROSIS AND MAGNETIC RESONANCE IMAGES
Author: Kelly, MP; Glover, NR; Cianci, PE
Abstract: BACKGROUND: Hyperbaric oxygen (HBO) is utilized in the treatment of delayed radiation injuries. Magnetic resonance imaging (MRI) can detect abnormalities found with radiation injuries to the central nervous system (CNS). We present a case of CNS STRN responsive to HBO documented by improved subjective symptoms, physical exam findings, and MRCASE REPORT: A previously healthy 28 year-old male presented with new onset grand mal seizures and dystaxia was diagnosed with a left-sided oligodendroglioma in Nov 2003. The patient underwent surgery and adjunctive radiation treatment. Several months later the patient experienced symptoms consistent with delayed radiation injury. The patient demonstrated poor memory, change in personality, left foot drop, left foot clonus, dystaxia, depressed left sided proprioreception, and proximal left leg weakness. MRI showed significant areas of necrosis and edema to the right frontal area that corresponded with physical exam findings. The patient underwent 40 HBO treatments at 2 atmospheres, for 2 hourRESULTS: Post treatment re-evaluation revealed a dramatic reversal of the physical examination abnormalities and symptomatic improvement with memory and personality. MRI performed 3 weeks after completion of HBO demonstrated significant reduction in edema/inflammation of the right pre-frontal cortex. These changes are felt to clinically correlate with the patient's subsequent improvement.CONSLUSIONS: HBO is documented to reduce edema in damaged tissues through hyperoxic vasoconstriction and reverse radiation necrosis and edema by salvaging damaged, dormant tissue with the stimulation of angiogenesis. These processes lead to the restoration of normal tissue function and the arrest of progressive delayed radiation injury. HBOT can be dramatically helpful in the treatment of clinically significant cases of CNS STRN associated with edema following radiotherapy. MRI can readily document the beneficial effect of HBO.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/3697
Date: 2006

Files in this item

Files Size Format View
abstract.txt 259bytes Text file View/Open

This item appears in the following Collection(s)

  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

Show full item record

Browse

My Account