[abstract] THE MEASUREMENT OF PERI-OPERATIVE LEUKOCYTE ADHERENCE IN PATIENTS UNDERGOING CARDIOPULMONARY BYPASS DURING CARDIAC SURGERY

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[abstract] THE MEASUREMENT OF PERI-OPERATIVE LEUKOCYTE ADHERENCE IN PATIENTS UNDERGOING CARDIOPULMONARY BYPASS DURING CARDIAC SURGERY

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Title: [abstract] THE MEASUREMENT OF PERI-OPERATIVE LEUKOCYTE ADHERENCE IN PATIENTS UNDERGOING CARDIOPULMONARY BYPASS DURING CARDIAC SURGERY
Author: Logue, CJ; Thom, SR; Sinha, A
Abstract: BACKGROUND: It is known that cardiopulmonary bypass (CPB) during cardiac surgery induces an inflammatory response. This inflammatory response may be implicated in a number of complications known to occur after CPB including post-operative cognitive dysfunction (POCD). Previous studies have demonstrated that CPB during cardiac surgery causes an up-regulation in the production of Beta-2 Integrin (CD11/CD18) on the surface of leukocytes. This would imply that leukocyte adherence increases in response to the increased cell surface expression of Beta-2 Integrin. However, to date, no functional study has ever been performed demonstrating and quantifying an increase in leukocyte adherence in patients undergoing cardiac surgery with CPB. Our hypothesis is that functional leukocyte adherence increases during and after cardiac surgery involving CPMATERIALS AND METHODS: Patients undergoing cardiac surgery with cardiopulmonary bypass are being recruited from the in-patient cardiothoracic surgery service. Blood samples are drawn prior to, during and at approximately 4hrs and 24hrs post-operatively. Functional leukocyte adhesion is then measured using using a previously described polymorphonuclear neutrophil (PMN) nylon adherence assaRESULTS: Patient Recruitment is occuring at this time. The results will be presenteCONLCUSIONS: It is likley that leukocyte adherence and subsequent activity plays a significant role in post-operative complications following cardiac surgery with CPB. Previous studies have shown that hyperbaric oxygen therapy inhibits Beta-2 integrin dependent leukocyte adherence in humans for up to 24hrs. Future research involving pre-operative prophylactic hyperbaric oxygen therapy to prevent immune mediated complications of CPB during cardiac surgery may be warranted.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/3654
Date: 2006

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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