Hyperbaric oxygen as a therapy of Bell's palsy

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Hyperbaric oxygen as a therapy of Bell's palsy

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Title: Hyperbaric oxygen as a therapy of Bell's palsy
Author: Racic, G; DeNoble, PJ; Sprem, N; Bojic, L; Bota, B
Abstract: The purpose of this study was to compare the therapeutic effects of hyperbaric oxygen (HBO2) to the effects of prednisone treatment in 79 subjects with Bell's palsy. Patients were randomly assigned either to the HBO2-treated group (n = 42) or to the prednisone-treated group (n = 37). The HBO2 group was exposed to 2.8 atm abs of 100 percent oxygen for 60 min, twice a day, 5 days a week and was given a placebo orally. The prednisone group was exposed to 2.8 atm abs of 7percent O2 (equivalent to 21percent O2 in air at normal pressure) following the same schedule as the HBO2 group; prednisone was given orally (total of 450 mg in 8 days). Subjects from both groups were treated in the hyperbaric chamber for up to 30 sessions or to complete recovery, and were followed up for 9 mo. At the end of the follow-up period, 95.2percent of subjects treated with HBO2, and 75.7percent of subjects treated with prednisone recovered completely. The average time to complete the recovery in the HBO2 group was 22 days as opposed to 34.4 days in the control group (P less than 0.001). In the HBO2-treated group, at the beginning, the altered nerve excitability test (NET) was abnormal in five subjects; three of them had normal NET by the end of the follow-up period. In the prednisone group the NET was abnormal in nine subjects at the beginning and they had not recovered by the end of the follow-up (P less than 0.05). Our results suggest that HBO2 is more effective than prednisone in treatment of Bell's palsy. Adolescent Adult Aged Anti-Inflammatory Agents/*therapeutic use Facial Paralysis/*therapy Female Follow-Up Studies Human *Hyperbaric Oxygenation Male Middle Aged Prednisone/*therapeutic use
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 9068154
http://archive.rubicon-foundation.org/2392
Date: 1997

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