Smoke inhalation - induced alveolar lung injury is inhibited by hyperbaric oxygen

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Smoke inhalation - induced alveolar lung injury is inhibited by hyperbaric oxygen

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dc.contributor.author Thom, SR en_US
dc.contributor.author Mendiguren, I en_US
dc.contributor.author Fisher, D en_US
dc.date.accessioned 2006-08-23T01:12:02Z
dc.date.available 2006-08-23T01:12:02Z
dc.date.issued 2001 en_US
dc.identifier.other Undersea Hyperb Med en_US
dc.identifier.uri PMID: 12153144 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/2381
dc.description Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.description.abstract Smoke-induced lung injury in rats was assessed in terms of histopathology, gross mortality, neutrophil accumulation and as capillary leak. Administration of hyperbaric oxygen (HBO2), 2.8 atm abs for 45 min, inhibited adhesion of circulating neutrophils subsequent to smoke inhalation. HBO2 reduced pulmonary neutrophil accumulation whether used in a prophylactic manner, 24 h before smoke inhalation, or as treatment immediately after the smoke insult Emphasis was placed on prophylactic administration of HBO2 to avoid the possibility that beneficial effects may be related to hastened removal of carbon monoxide. Based on all parameters tested, smoke inhalation injury was reduced by prophylactic aadministration of HBO2. The beneficial effect appears related to inhibition of neutroophil adhesion to the vasculature. en_US
dc.format.extent 1317403 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.source.uri null en_US
dc.subject neutrophil en_US
dc.subject pulmonary en_US
dc.subject hyperbaric en_US
dc.subject Smoke inhalation en_US
dc.subject alveolar lung injury en_US
dc.title Smoke inhalation - induced alveolar lung injury is inhibited by hyperbaric oxygen en_US

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