Modulation of sensitivity to hyperbaric oxygen by CO2 in newborn rats

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Modulation of sensitivity to hyperbaric oxygen by CO2 in newborn rats

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dc.contributor.author Torbati, D en_US
dc.contributor.author Peyman, GA en_US
dc.contributor.author Rodriguez, JA en_US
dc.contributor.author Navarro, GC en_US
dc.date.accessioned 2006-08-23T01:10:33Z
dc.date.available 2006-08-23T01:10:33Z
dc.date.issued 1995 en_US
dc.identifier.other Undersea Hyperb Med en_US
dc.identifier.uri PMID: 7580762 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/2216
dc.description Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.description.abstract We examined the modifying effects of CO2 on the CNS and pulmonary manifestations of hyperbaric oxygenation (HBO) in newborn rats. Four- to seven-day-old rats were exposed to HBO with inspired PCO2 (PICO2) of approximately 0, 60, 90, 140, 190, and 380 mmHg at a total pressure of 5 atm abs. The PCO2 values studied corresponded with 0, 8, 12, 18, 25, and 50 kPa, respectively, at a total pressure of 507 kPa. The O2-CO2 exposures lasted for 2-8 h. Hypercapnia at PICO2 of 60 and 90 mmHg with HBO produced extensive pulmonary damage with a high post-decompression mortality, compared to HBO alone. In contrast, PICO2 at the anesthetic levels of 140 and 190 mmHg attenuated the visible pulmonary and neurologic manifestations of O2 toxicity, and significantly reduced post-decompression mortality, compared to moderate hypercapnia of 60-90 mmHg. Supercapnia, at PICO2 of 380 mmHg, with HBO also produced no visible neurologic effect, but it caused an early apnea with severe pulmonary damage. These data indicate unique and dose-dependent cerebral and pulmonary responses to hyperoxic-hypercapnia in newborn rats. It is speculated that anesthetic levels of hypercapnia may be utilized to improve tissue oxygenation during O2 therapy in newborns, without increasing the risk of pulmonary and CNS O2 poisoning. en_US
dc.format.extent 1708653 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.source.uri null en_US
dc.subject HBO en_US
dc.subject CO2 en_US
dc.subject carbon dioxide en_US
dc.subject pulmonary en_US
dc.subject hyperbaric en_US
dc.subject animal en_US
dc.subject rat en_US
dc.subject.mesh Animals Animals, Newborn Carbon Dioxide/blood Carbon Dioxide/pharmacology* Female Hyperbaric Oxygenation/adverse effects* Hypercapnia/complications Male Nervous System Diseases/blood Nervous System Diseases/etiology* Oxygen/poisoning Partial Pressure Rats Rats, Sprague-Dawley Respiration/physiology* Time Factors en_US
dc.title Modulation of sensitivity to hyperbaric oxygen by CO2 in newborn rats en_US

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