Hyperbaric oxygenation treatments and metabolic enzymes in the heart and diaphragm

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Hyperbaric oxygenation treatments and metabolic enzymes in the heart and diaphragm

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dc.contributor.author Nelson, AG en_US
dc.contributor.author Wolf Jr, EG en_US
dc.contributor.author Hearon, CM en_US
dc.contributor.author Li, B en_US
dc.date.accessioned 2006-08-23T01:10:09Z
dc.date.available 2006-08-23T01:10:09Z
dc.date.issued 1994 en_US
dc.identifier.other Undersea Hyperb Med en_US
dc.identifier.uri PMID: 8061560 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/2172
dc.description Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.description.abstract We previously found that intermittent hyperbaric oxygen exposure increases metabolic enzyme activity in soleus muscle. Since the metabolic enzyme activities of the heart and diaphragm of healthy animals are difficult to alter, we questioned whether intermittent hyperbaric oxygenation would provide a stimulus sufficient to increase metabolic enzyme activity. Therefore, we exposed 36 rabbits (4 groups of 9) twice daily for 90 min 5 days/wk to either 100% O2 at 243 kPa, 8.5% O2, and 91.5% N2 at 243 kPa, 100% O2 at 101 kPa, or 21% O2 at 101 kPa. After 4 wk of treatment, the activities of citrate synthase, succinate dehydrogenase, alpha-glycerophosphate dehydrogenase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase were measured. In both the heart and the diaphragm, none of the treatments significantly altered the mean enzyme activities for any of the enzymes measured. Therefore, it seems that the hyperbaric oxygenation treatment protocols used do not induce an increase in metabolic enzyme activity in the heart and diaphragm in healthy animals. en_US
dc.format.extent 972627 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.source.uri null en_US
dc.subject hyperbaric en_US
dc.title Hyperbaric oxygenation treatments and metabolic enzymes in the heart and diaphragm en_US

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