[abstract] BISPHOSPHONATE ASSOCIATED OSTEONECROSIS OF THE JAWS: A RETROSPECTIVE CASE SERIES AND REVIEW OF THE LITERATURE

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[abstract] BISPHOSPHONATE ASSOCIATED OSTEONECROSIS OF THE JAWS: A RETROSPECTIVE CASE SERIES AND REVIEW OF THE LITERATURE

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Title: [abstract] BISPHOSPHONATE ASSOCIATED OSTEONECROSIS OF THE JAWS: A RETROSPECTIVE CASE SERIES AND REVIEW OF THE LITERATURE
Author: Boneta, O; Kraft, KL; Daniels, D
Abstract: BACKGROUND: Reports of osteonecrosis of the jaw associated with intravenous bisphosphonate therapy for the management of bone disease from cancer, in patients without prior radiation therapy, first appeared in the Oral Surgery literature in 2003. Since that time there have been less than 100 reported cases in the medical literature. There have been no reports in the Hyperbaric Medicine literature. We report 14 patients with this condition referred for evaluation at the Duke Center for Hyperbaric Medicine and Environmental Physiology from May 1997 - December 2004. MATERIALS AND METHODS: Retrospective chart review of all patients referred to the Duke Center for Hyperbaric Medicine with a history of intravenous bisphosphonate therapy and oral non-healing wounds and no prior history of radiation therapy to the head and neck. For each case, 16 pieces of information were collected using the Duke Hyperbaric Medicine database and the Duke University Medical Center medical record. RESULTS: All patients received, or were still receiving, long-term intravenous therapy with pamidronate or zoledronate prior to developing their non-healing jaw wounds. None of the patients had received head and neck radiation therapy. Unlike osteoradionecrosis, these lesions tend not to respond well to standard antibiotic, surgical, or hyperbaric oxygen therapy. CONCLUSIONS: There appears to be a temporal association between long-term bisphosphonate therapy and osteonecrosis of the jaw. At this time, non-surgical palliative care, if possible, seems to be the best course of action. Further research is needed to evaluate for the relationship between IV bisphosphonate therapy and osteonecrosis of the jaw and to determine optimal therapy for these patients.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1651
Date: 2005

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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